中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (7): 3026-3034.doi: 10.4103/NRR.NRR-D-24-01279

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

脑卒中患者双侧上肢训练期间神经和肌肉活动的相关性:一项横断面研究

  

  • 出版日期:2026-07-15 发布日期:2026-03-27

Investigating the correlation between neural and muscular activities during bilateral arm training in stroke survivors: A cross-sectional study

Yan Tang1, Tara Scarlette Rosalyn Chen2, Yi Xu1, Pu Wang1, Peng Dou1, Dongfeng Huang1, 3, *   

  1. 1Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, China;
    2The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China; 
    3Guangdong Engineering and Technology Research Center for Rehabilitation Medicine and Translation, Guangzhou, Guangdong Province, China
  • Online:2026-07-15 Published:2026-03-27
  • Contact: Dongfeng Huang, MD, huangdf@mail.sysu.edu.cn or huangdongfeng@sysush.com.

摘要:

脑卒中后,多数患者会出现不同程度的上肢功能功能障碍。双侧上肢训练可帮助脑卒中患者恢复运动,但尚不完全了解大脑和肌肉在这种训练中是如何协同工作的。因此在中国中山大学附属第七医院进行的一项病例对照研究中,观察了21例脑卒中患者和17名健康对照在双侧上肢训练期间大脑和肌肉活动之间的联系。通过功能性近红外光谱和表面肌电图分别检测大脑皮质氧合变化和上肢肌肉收缩信号。结果显示,在双侧上肢训练中与健康对照组相比,脑卒中患者功能连接性降低,而患侧屈肌出现更多不规则的肌肉活动,且脑卒中患者多个脑区表面肌电图信号特征与脑氧合指标存在显著相关性。这些发现表明双侧上肢训练是一种有效的康复方法,能够通过促进大脑功能连接和改善肌肉活动模式,改善脑卒中患者的上肢运动功能。


https://orcid.org/0000-0002-7958-4082 (Dongfeng Huang); 

https://orcid.org/0009-0008-4119-0687 (Yan Tang)

关键词:  脑卒中, 偏瘫, 近红外光谱, 表面肌电图, 神经可塑性, 双侧上肢训练, 协调性, 熵, 功能连接, 相互作用

Abstract: Stroke patients experience varying degrees of upper limb functional impairment. Although bilateral arm training can help stroke patients recover movement after stroke, little is known about the way in which the brain and muscles work together during this type of training. To address this, we conducted a cross-sectional study at The Seventh Affiliated Hospital, Sun Yat-sen University in China, where we observed the connection between brain and muscle activity during bilateral upper limb training in 21 stroke patients and 17 healthy controls. We used functional near-infrared spectroscopy and surface  electromyography to measure changes in cerebral cortex oxygenation and upper limb muscle contraction signals, respectively. The results showed that, compared with the healthy control group, stroke patients had reduced functional connectivity and more irregular muscle activity in the affected flexor muscle during bilateral upper limb training. Moreover, we found a significant correlation between the surface electromyographic signal characteristics of upper limb muscles and cerebral oxygenation indicators of multiple brain regions in stroke patients. These findings indicate that bilateral upper limb training is an effective rehabilitation method that improves upper limb motor function in stroke patients by promoting brain functional connectivity and improving muscle activity patterns.

Key words: bilateral arm training, coordination, entropy, functional connectivity, hemiparesis, interaction, near-infrared spectroscopy, neuroplasticity, stroke, surface electromyography