中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 1058-1073.doi: 10.4103/NRR.NRR-D-24-00924

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

lncRNA对缺血性脑卒中的调控及应用前景

  

  • 出版日期:2026-03-15 发布日期:2025-07-02
  • 基金资助:
    此研究得到中国博士后科学基金（2022M712689）、江苏省高等学校自然科学基金（22KJB1800029）、扬州大学大学生创新项目（CX20240856）和江苏省科技人才项目（FZ20240964）的资助。

LncRNA regulation in ischemic stroke and their application prospects

Qianqian Chen1 , Xiangyi Xu1 , Shun Li2, *, Tianqing Xiong1, 2, 3, *   

  1. 1 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China;  2 Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;  3 Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Yangzhou University, Yangzhou, Jiangsu Province, China
  • Online:2026-03-15 Published:2025-07-02
  • Contact: Tianqing Xiong, PhD, 007418@yzu.edu.cn; Shun Li, MD, lis24@upmc.edu.
  • Supported by:
    This work was supported by the China Postdoctoral Science Foundation, No. 2022M712689; the Natural Science Foundation of the Jiangsu Higher Education Institutions of China, No. 22KJB1800029; The University Student Innovation Project of Yangzhou University, No. XCX20240856; The Jiangsu Provincial Science and Technology Talent Project, No. FZ20240964 (all to TX).

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摘要：

缺血性脑卒中是一种无法提前预知的严重医疗事件，可对家庭和社会造成长期影响。深入了解遗传表现的变化和基本的分子控制机制有助于解决这一关键问题。在过去的几年里，对具有调控功能的各类 RNA 分子，如调控性长链非编码 RNA的研究已成为缺血性脑卒中研究领域的一大进步。此综述试图深入探讨调控性长链非编码 RNA在缺血性脑卒中中的功能以及应用于临床的潜在策略。长链非编码 RNA有可能作为一种引诱剂吸引特定的微小RNA，并通过 “海绵效应 ”调控 miRNA 靶基因的表达。这种相互作用影响缺血性脑卒中的各个方面，包括再灌注诱导的损伤、细胞死亡、免疫反应、自我降解、血管形成和活性氧等情况。文章列出了用于动物模型干预的调控长链非编码 RNA，包括长链非编码 RNA NKILA、长链非编码 RNA Meg8和长链非编码 RNA H19，以及被用作缺血性脑卒中诊断和预测指标的长链非编码 RNA，如长链非编码 RNA FOXO3、长链非编码 RNA Xist和长链非编码 RNA RMST。这些长链非编码 RNA有望用于从基因层面治疗缺血性脑卒中。然而，由于长链非编码 RNA应用时具有低效率、低靶向性和不良反应的局限性，因此将 长链非编码 RNA应用于缺血性脑卒中是一项挑战，未来需要进行细致而深入的验证。

https://orcid.org/0000-0001-6497-7847 (Tianqing Xiong); https://orcid.org/0000-0001-8601-2261 (Shun Li)

关键词: AAV, 血管生成, 自噬, 基因治疗, 长非编码 RNA, 神经炎症, 氧化应激, 病理生理机制, 缺血性脑卒中, 脑卒中

Abstract: Ischemic stroke is a serious medical event that cannot be predicted in advance and can have longlasting effects on patients, families, and communities. A deeper understanding of the changes in gene expression and the fundamental molecular mechanisms involved could help address this critical issue. In recent years, research into regulatory long non-coding (lnc)RNAs, a diverse group of RNA molecules with regulatory functions, has emerged as a promising direction in the study of cerebral infarction. This review paper aims to provide a comprehensive exploration of the roles of regulatory lncRNAs in cerebral infarction, as well as potential strategies for their application in clinical settings. LncRNAs have the potential to act as “sponges” that attract specific microRNAs, thereby regulating the expression of microRNA target genes. These interactions influence various aspects of ischemic stroke, including reperfusion-induced damage, cell death, immune responses, autophagy, angiogenesis, and the generation of reactive oxygen species. We highlight several regulatory lncRNAs that have been utilized in animal model treatments, including lncRNA NKILA, lncRNA Meg8, and lncRNA H19. Additionally, we discuss lncRNAs that have been used as biomarkers for the diagnosis and prognosis of cerebral infarction, such as lncRNA FOXO3, lncRNA XIST, and lncRNA RMST. The lncRNAs hold potential for genetic-level treatments in patients. However, numerous challenges, including inefficiency, low targeting accuracy, and side effects observed in preliminary studies, indicate the need for thorough investigation. The application of lncRNAs in ischemic stroke presents challenges that require careful and extensive validation.

Key words: adeno-associated virus, angiogenesis, autophagy, gene therapy, ischemic stroke, long non-coding RNAs, neuroinflammation, oxidative stress, pathophysiological mechanism, stroke