关键词: 神经再生, 神经退行性变, 弥漫性轴索损伤, 髓鞘碎片, 神经炎症, 创伤性脑损伤, 头部外伤, 中枢神经系统, 炎症, 轴突, 预后, 国家自然科学基金

Abstract:

The accumulation of myelin debris may be a major contributor to the inflammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus and brain stem to identify the myelin debris. Seven days after diffuse axonal injury, many Oil Red O-stained particles were observed in the cerebral cortex, hippocampus and brain stem. In the cerebral cortex and hippocampus, the amount of myelin debris peaked at 14 days after injury, and decreased significantly at 28 days. In the brain stem, the amount of myelin debris peaked at 7 days after injury, and decreased significantly at 14 and 28 days. In the cortex and hippocampus, some myelin debris could still be observed at 28 days after diffuse axonal injury. Our findings suggest that myelin debris may persist in the rat central nervous system after diffuse axonal injury, which would hinder recovery.

Key words: nerve regeneration, neurodegeneration, diffuse axonal injury, myelin debris, neuroinflammation, traumatic brain injury, head trauma, central nervous system, inflammation, axon, prognosis, NSFC grants, neural regeneration