中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 957-971.doi: 10.4103/NRR.NRR-D-24-00434

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤多靶点神经环路的重建与增强

  

  • 出版日期:2026-03-15 发布日期:2025-07-02

Multi-target neural circuit reconstruction and enhancement in spinal cord injury

Lingyun Cao1, 2, 3, #, Siyun Chen1, 4, #, Shuping Wang1, 2, 3, Ya Zheng5, *, Dongsheng Xu1, 2, 3, 6, *   

  1. 1 School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; 2 Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China; 3 Institute of Rehabilitation Medicine, Shanghai, China; 4 Department of Rehabilitation Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China; 5 Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China; 6 Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • Online:2026-03-15 Published:2025-07-02
  • Contact: Ya Zheng, MD, alice_612_zheng@alumni.tongji.edu.cn; Dongsheng Xu, PhD, dxu0927@shutcm.edu.cn.
  • Supported by:
    This work was supported by the National Key Research and Development Program of China, No. 2023YFC3603705 (to DX); the National Natural Science Foundation of China, No. 82302866 (to YZ).

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摘要：

脊髓损伤后，感觉运动回路的损伤可能导致运动、感觉、本体感觉和自主神经系统功能障碍。而干预的时间窗局限性和干预方法的限制会导致功能恢复的瓶颈。为应对这些挑战，已设计了一系列技术来帮助在脊髓损伤不同阶段中修复和重建神经环路。值得注意的是，神经调控因其在增强神经再生、神经保护和神经元恢复以及调节大脑皮质和皮质脊髓束内回路的神经重组方面的潜力而备受关注。为提高这些干预措施的有效性，建议实施多靶点早期介入神经调控策略（如电刺激和磁刺激），以增强神经损伤不同阶段的功能恢复。此次综述简要概述了脊髓损伤修复遇到的挑战，综合了现有的神经刺激技术，重点是受损连接的神经保护、修复和再生，探讨了多靶区、任务导向干预框架中时机选择的重要性，并强调了早期干预在脊髓损伤治疗结果和康复过程中起到的关键作用。

https://orcid.org/0000-0003-3704-9724 (Ya Zheng); https://orcid.org/0000-0002-8477-5377 (Dongsheng Xu)

关键词: 脊髓损伤, 神经调控, 多靶点, 时机, 神经环路, 重建, 神经根磁刺激, 周围神经刺激, 经颅磁刺激, 任务导向训练

Abstract: After spinal cord injury, impairment of the sensorimotor circuit can lead to dysfunction in the motor, sensory, proprioceptive, and autonomic nervous systems. Functional recovery is often hindered by constraints on the timing of interventions, combined with the limitations of current methods. To address these challenges, various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury. Notably, neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration, provide neuroprotection, restore neurons, and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract. To improve the effectiveness of these interventions, the implementation of multitarget early interventional neuromodulation strategies, such as electrical and magnetic stimulation, is recommended to enhance functional recovery across different phases of nerve injury. This review concisely outlines the challenges encountered following spinal cord injury, synthesizes existing neurostimulation techniques while emphasizing neuroprotection, repair, and regeneration of impaired connections, and advocates for multi-targeted, task-oriented, and timely interventions.

Key words: multi-targets, nerve root magnetic stimulation, neural circuit, neuromodulation, peripheral nerve stimulation, reconstruction, spinal cord injury, task-oriented training, timing, transcranial magnetic stimulation