中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (9): 1544-1555.doi: 10.4103/1673-5374.255976

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

静息态脑功能连接随衰老发生的相关变化

  

  • 出版日期:2019-09-15 发布日期:2019-09-15
  • 基金资助:

    加拿大通用2014年SGR 326综合研究小组（GRC）和Ministerio de PSI2013-41400-P项目资助

Age-related changes in resting-state functional connectivity in older adults

Laia Farràs-Permanyer 1 , Núria Mancho-Fora 1, 3 , Marc Montalà-Flaquer 1 , David Bartrés-Faz 2, 4 , Lídia Vaqué-Alcázar 2 , Maribel Peró-Cebollero 1, 3 , Joan Guàrdia-Olmos 1, 3   

  1. 1 Quantitative Psychology Section, Faculty of Psychology, University of Barcelona, Barcelona, Spain
    2 Department of Medicine, Faculty of Medicine and Healthy Sciences, University of Barcelona, Barcelona, Spain
    3 Institute of Neuroscience, UB Institute of Complex Systems, University of Barcelona, Barcelona, Spain
    4 Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
  • Online:2019-09-15 Published:2019-09-15
  • Contact: Laia Farràs-Permanyer, PhD, laiafarras@ub.edu.
  • Supported by:

    This study was supported by the Grup de Recerca en Tècniques Estadístiques Avançades Aplicades a la Psicologia (GTEAAP) members of the Generalitat de Catalunya’s 2014 SGR 326 Consolidated Research Group (GRC) and was made possible by the PSI2013-41400-P project of Ministerio de Economia y Competitividad of the Spanish Government.

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摘要：

健康老年人大脑连接的年龄相关变化已被广泛研究，且主要以老年与青年受试者的对比研究为多见，尚未得到统一结论。此次观察的性研究以114名48-89岁的健康中老年人为研究对象，并将其分为<60岁,60-64岁,65-69岁,70-74岁,75-79岁，> 80岁6个不同年龄组，应用静息态功能性磁共振成像对比分析不同年龄段健康中老年人脑功能连接及其网络特征。偏相关分析和总体相关分析和具有显著连接性的3循环区域的研究结果显示，总体趋势为随着年龄的增加，脑功能连接逐渐减少，尤以75-79岁这一年龄段最为显著；而在年龄> 80岁的人群中，脑功能连接反而略有增加，可能与大脑功能的代偿机制有关。这项研究呈现了健康中老年人群大脑功能连接特征信息，并为研究功能连接特征方法提供了有效工具。该研究于2012年6月5日获得巴塞罗那大学医学院伦理委员会（PSI2012-38257）批准，分别于2009年10月22日和2011年4月7日获得巴塞罗那医院Clínic的伦理委员会批准（2009-5306和2011-6604）。

orcid: 0000-0002-2674-1101 (Laia Farràs-Permanyer)

关键词: 大脑连通性, 休息状态, DMN, 老化, 健康, 功能连接, RSN, 年龄组

Abstract:

Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years, with some differences in the obtained results. Most of these studies showed decreases in general functional connectivity, but they also found increases in some particular regions and areas. Frequently, these studies compared young individuals with older subjects, but few studies compared different age groups only in older populations. The purpose of this study is to analyze whole-brain functional connectivity in healthy older adult groups and its network characteristics through functional segregation. A total of 114 individuals, 48 to 89 years old, were scanned using resting-state functional magnetic resonance imaging in a resting state paradigm and were divided into six different age groups (< 60, 60–64, 65–69, 70–74, 75–79, ≥ 80 years old). A partial correlation analysis, a pooled correlation analysis and a study of 3-cycle regions with prominent connectivity were conducted. Our results showed progressive diminution in the functional connectivity among different age groups and this was particularly pronounced between 75 and 79 years old. The oldest group (≥ 80 years old) showed a slight increase in functional connectivity compared to the other groups. This occurred possibly because of compensatory mechanism in brain functioning. This study provides information on the brain functional characteristics of every age group, with more specific information on the functional progressive decline, and supplies methodological tools to study functional connectivity characteristics. Approval for the study was obtained from the ethics committee of the Comisión de Bioética de la Universidad de Barcelona (approval No. PSI2012-38257) on June 5, 2012, and from the ethics committee of the Barcelona’s Hospital Clínic (approval No. 2009-5306 and 2011-6604) on October 22, 2009 and April 7, 2011 respectively.

Key words: brain connectivity, resting state, default mode network, aging, healthy, functional connectivity, resting state network, age groups