中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (5): 944-954.doi: 10.4103/1673-5374.297061

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

针刺治疗缺血性脑卒中的机制:炎症信号传递和调节

  

  • 出版日期:2021-05-15 发布日期:2020-12-29
  • 基金资助:

    国家自然科学基金项目(810729478147347081774423);广东省自然科学基金项目(2014A030311033

Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation

Bing-Qian Cao1, Feng Tan1, *, Jie Zhan2, Peng-Hui Lai3   

  1. 1 Department of Neurology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong Province, China;  2 Department of Rehabilitation, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong Province, China;  3 Department of Rehabilitation, Nan’ao People’s Hospital Dapeng New District, Shenzhen, Guangdong Province, China
  • Online:2021-05-15 Published:2020-12-29
  • Contact: Feng Tan, PhD, tanfeng8208@163.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 81072947, 81473470, 81774423, the Natural Science Foundation of Guangdong Province of China, No. 2014A030311033 (all to FT).

摘要: https://orcid.org/0000-0002-5052-8642 (Feng Tan) 

关键词:

中枢神经系统, 卒中, 缺血性卒中, 针刺, 蛋白, 因子, 通路, 炎症

Abstract: The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair. After cerebral ischemia/reperfusion, microglia are activated, and a large number of circulating inflammatory cells infiltrate the affected area. This leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage, including neuron necrosis, blood-brain barrier destruction, cerebral edema, and an oxidative stress response. Activation of inflammatory signaling pathways plays a key role in the pathological process of ischemic stroke. Increasing evidence suggests that acupuncture can reduce the inflammatory response after cerebral ischemia/reperfusion and promote repair of the injured nervous system. Acupuncture can not only inhibit the activation and infiltration of inflammatory cells, but can also regulate the expression of inflammation-related cytokines, balance the effects of pro-inflammatory and anti-inflammatory factors, and interfere with inflammatory signaling pathways. Therefore, it is important to study the transmission and regulatory mechanism of inflammatory signaling pathways after acupuncture treatment for cerebral ischemia/reperfusion injury to provide a theoretical basis for clinical treatment of this type of injury using acupuncture. Our review summarizes the overall conditions of inflammatory cells, mediators, and pathways after cerebral ischemia/reperfusion, and discusses the possible synergistic intervention of acupuncture in the inflammatory signaling pathway network to provide a foundation to explore the multiple molecular mechanisms by which acupuncture promotes nerve function restoration.

Key words: acupuncture, central nervous system, factor, inflammation, ischemic stroke, pathways, protein, stroke