中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (9): 843-852.doi: 10.3969/j.issn.1673-5374.2013.09.009

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

ERK-CREB-BDNF信号转导通路与抑郁症

  

  • 收稿日期:2012-12-10 修回日期:2013-01-20 出版日期:2013-03-25 发布日期:2013-03-25
  • 基金资助:

    国家自然科学基金，No:81202620；山东省高校青年骨干教师国内访问学者项目

Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/ brain-derived neurotrophic factor signal transduction pathway in depressive disorder

Hongyan Wang1, 2, Yingquan Zhang3, Mingqi Qiao1   

  1. 1 Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
    2 Taishan Medical University, Taian 271000, Shandong Province, China
    3 Taian Hospital of Traditional Chinese Medicine, Taian 271000, Shandong Province, China
  • Received:2012-12-10 Revised:2013-01-20 Online:2013-03-25 Published:2013-03-25
  • Contact: Mingqi Qiao, Ph.D., Doctoral supervisor, Professor, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China, qmingqi@163.com.
  • About author:Hongyan Wang☆, Studying for doctorate, Associate professor.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 81202620, and the Domestic Visiting Scholar Program for Young Talent Teachers in University of Shandong Province.

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摘要：

ERK-CREB-BDNF信号转导通路是近几年来研究抑郁症发病机制的一项重要发现，在介导抗抑郁药物发挥作用中表现出明显的优势。文章综述了ERK-CREB-BDNF信号转导通路在抑郁症发病及抗抑郁药物治疗中的重要作用。ERK-CREB-BDNF信号转导通路作为一项生物学指标，对抑郁症的临床诊断有指导意义，在临床治疗方面，ERK-CREB-BDNF信号转导通路或许是抑郁症治疗的新靶点。

关键词: 神经再生, 综述, 抑郁症, 丝裂原活化蛋白激酶通路, 胞外信号调节激酶, 环磷腺苷反应元件结合蛋白, 脑源性神经营养因子, 5-羟色胺, 信号通路, 心境障碍, 神经元, 可塑性, 基金资助文章

Abstract:

The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway plays an important role in the mechanism of action of antidepressant drugs and has dominated recent studies on the pathogenesis of depression. In the present review we summarize the known roles of extracellular signal-regulated kinase, cAMP response element-binding protein and brain-derived neurotrophic factor in the pathogenesis of depression and in the mechanism of action of antidepressant medicines. The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor pathway has potential to be used as a biological index to help diagnose depression, and as such it is considered as an important new target in the treatment of depression.

Key words: neural regeneration, reviews, depression, mitogen-activated protein kinase, extracellular signal-regulated kinase, cAMP response element-binding protein, brain-derived neurotrophic factor, 5-hydroxytryptamine, grants-supported paper, neuroregeneration