中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (10): 916-921.doi: 10.3969/j.issn.1673-5374.2013.10.006

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

脑缺血再灌注损伤远期和转录因子的改变

  

  • 收稿日期:2012-09-15 修回日期:2013-01-04 出版日期:2013-04-05 发布日期:2013-04-05

Transcription factor changes following long term cerebral ischemia/reperfusion injury

Hongbo Zhang1, Weijuan Gao2, Tao Qian3, Jinglong Tang1, Jun Li1   

  1. 1 Department of Pathophysiology, Chengde Medical College, Chengde 067000, Hebei Province, China
    2 Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026, Hebei Province, China
    3 Hebei Provincial People's Hospital, Shijiazhuang 050051, Hebei Province, China
  • Received:2012-09-15 Revised:2013-01-04 Online:2013-04-05 Published:2013-04-05
  • Contact: Weijuan Gao, M.D, Ph.D., Professor, Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026, Hebei Province, China, gwj6088@ 163.com.
  • About author:Hongbo Zhang★, Master, Lecturer.

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摘要：

以四血管阻断法制备脑缺血再灌注损伤大鼠，海马CA1区神经元形态受损，神经元数量减少，海马组织cAMP反应元件结合蛋白、CCAAT/增强子结合蛋白的DNA结合活性降低，大鼠学习和记忆能力下降。提示cAMP反应元件结合蛋白和CCAAT/增强子结合蛋白的DNA结合活性下降，可能参与脑缺血再灌注损伤引起的神经元损伤和学习记忆能力下降。

关键词: 神经再生, 脑损伤, 脑缺血再灌注, 海马组织, cAMP反应元件结合蛋白, CCAAT/增强子结合蛋白, DNA结合活性, 脑, 基金资助项目

Abstract:

The present study established a rat model of cerebral ischemia/reperfusion injury using four-vessel occlusion and found that hippocampal CA1 neuronal morphology was damaged, and that there were reductions in hippocampal neuron number and DNA-binding activity of cAMP response element binding protein and CCAAT/enhancer binding protein, accompanied by decreased learning and memory ability. These findings indicate that decline of hippocampal cAMP response element binding protein and CCAAT/enhancer binding protein DNA-binding activities may contribute to neuronal injury and learning and memory ability reduction induced by cerebral ischemia/reperfusion injury.

Key words: neural regeneration, brain injury, cerebral ischemia/reperfusion, hippocampus, cAMP response element binding protein, CCAAT/enhancer binding protein, DNA-binding activity, brain, grants-supported paper, neuroregeneration