中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (11): 975-982.doi: 10.3969/j.issn.1673-5374.2013.11.002

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

羊膜修复面神经损伤

  

  • 收稿日期:2013-02-15 修回日期:2013-04-01 出版日期:2013-04-15 发布日期:2013-04-15

Chondroitinase ABC plus bone marrow mesenchymal stem cells for repair of spinal cord injury

Murat Karaman1, Arzu Tuncel2, Shahrouz Sheidaei2, Mehmet Güney Şenol3, Murat Hakan Karabulut1, Ildem Deveci1, Nihan Karaman4   

  1. 1 Department of Otorhinolaryngology, Ümraniye State Hospital for Research and Training, ?stanbul, Turkey
    2 Department of Otorhinolaryngology, Haydarpa?a Numune State Hospital for Research and Training, ?stanbul, Turkey
    3 Department of Neurology, GATA Haydarpa?a State Hospital for Research and Training, ?stanbul, Turkey
    4 Department of Dentistry, Turkish Military Services, ?stanbul, Turkey
  • Received:2013-02-15 Revised:2013-04-01 Online:2013-04-15 Published:2013-04-15
  • Contact: Murat Karaman☆, M.D., Department of Otorhinolaryngology, ümraniye State Hospital for Research and Training, ?stanbul, Turkey, karaman1398@yahoo.com.

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摘要：

由于羊膜的抗炎等特性，已被广泛应用于眼科和皮肤损伤的修复。那么是否可应用于面神经损伤的修复，而效果又将如何呢？实验将8只大鼠面神经完全切断后行端端吻合，然后将羊膜覆盖在其中4只大鼠的吻合口处。肌电图检测到，吻合后3和8周，羊膜覆盖的面神经潜伏期明显缩短，波幅明显升高。组织病理检测到，吻合后8周，羊膜覆盖的面神经连续性更好，炎症反应更轻。说明羊膜覆盖物更有利于面神经损伤的修复。

关键词: 神经再生, 周围神经损伤, 组织工程, 羊膜, 面神经, 损伤, 肌电图, 神经吻合, 炎症, 组织病理

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