中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (19): 1765-1772.doi: 10.3969/j.issn.1673-5374.2013.19.004
中药醒脑解郁胶囊治疗脑卒中后慢性应激抑郁效果等同于氟西汀
The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine
Yongmei Yan1, 2, Wentao Fan1, 2, Li Liu3, Ru Yang1, Wenjia Yang1
- 1 Department of Encephalopathy, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China
2 Encephalopathology Key Subject of Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine of the People’s Republic of China, Xianyang 712000, Shaanxi Province, China
3 Research Room of Traditional Chinese Medicine Internal Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
摘要：
中药醒脑解郁胶囊已被证明可有效减轻神经功能缺损，缓解抑郁症患者抑郁症状。那么，能否治疗卒中后慢性应激抑郁？鉴于此，实验采用左侧大脑中动脉阻塞法联合慢性不可预见的温和性刺激及孤养法建立脑卒中后抑郁大鼠模型，用醒脑解郁胶囊中药粉0.82，0.41，0.20 g/kg分别溶于2 mL蒸馏水灌胃干预，以盐酸氟西汀作为抗抑郁药物阳性对照，治疗28 d。糖水消耗实验、旷野试验、实时荧光定量PCR及免疫组织化学染色结果显示，不同剂量的醒脑解郁胶囊灌胃后脑卒中后抑郁大鼠糖水消耗量增加，自发活动行为增加，海马区突触结合蛋白的mRNA及蛋白表达明显增强，与盐酸氟西汀组疗效相近。证实醒脑解郁胶囊上调脑卒中后抑郁大鼠海马区突触结合蛋白的表达，以此发挥抗抑郁作用。