中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (19): 1814-1822.doi: 10.3969/j.issn.1673-5374.2013.19.009

• 原著:脑损伤修复保护与再生 • 上一篇    

组胺H3受体拮抗剂作用于突触后H1受体治疗新生儿缺氧缺血性脑病

  

  • 收稿日期:2013-03-20 修回日期:2013-05-25 出版日期:2013-07-05 发布日期:2013-07-05

Thioperamide treats neonatal hypoxic-ischemic encephalopathy by postsynaptic H1 receptors

Feiyong Jia, Lin Du, Yunpeng Hao, Shicheng Liu, Ning Li, Huiyi Jiang   

  1. Division of Pediatric Neurorehabilitation, Department of Pediatrics, Second Part of First Hospital of Jilin University, Changchun 130031, Jilin Province, China
  • Received:2013-03-20 Revised:2013-05-25 Online:2013-07-05 Published:2013-07-05
  • Contact: Huiyi Jiang, Ph.D., Attending physician, Division of Pediatric Neurorehabilitation, Department of Pediatrics, Second Part of First Hospital of Jilin University, Changchun 130031, Jilin Province, China, lliung@163.com.
  • About author:Feiyong Jia, Ph.D., Associate professor.

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摘要：

研究已表明，H3受体拮抗剂thioperamide能够增加脑内组胺含量，改善脑水肿，发挥神经保护作用。实验观察thioperamide对新生儿缺氧缺血性脑病模型大鼠脑水肿的影响及相关机制。结果发现，给予thioperamid后，新生儿缺氧缺血性脑病模型大鼠脑含水量及丙二醛含量明显下降，海马内组胺水平和脑组织超氧化物歧化酶活性明显增高。说明thioperamide可拮抗新生儿缺氧缺血性脑病的氧化损伤，减轻脑水肿。实验进一步观察H1受体拮抗剂吡拉明和H2受体拮抗剂西咪替丁分别与thioperamide联用后上述指标的变化。结果发现吡拉明可逆转thioperamide的作用，而西咪替丁对thioperamide的作用无显著影响。可见thioperamide可通过作用于突触后H1受体增加脑内组胺含量，减轻新生儿缺氧缺血性脑病模型大鼠的脑水肿及氧化损伤。

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