中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (29): 2725-2733.doi: 10.3969/j.issn.1673-5374.2013.29.004

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

窖蛋白（caveolin-1）表达下调导致老龄大鼠海马突触可塑性下降

  

  • 收稿日期:2013-02-16 修回日期:2013-08-26 出版日期:2013-10-15 发布日期:2013-10-15

Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats

Yang Liu1, Zhanhua Liang2, Jing Liu1, Wei Zou3, Xiaoyan Li1, Yachen Wang2, Lijia An4   

  1. 1 Regenerative Medicine Center, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning Province, China
    2 Department of Neurology, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning Province, China
    3 Department of Biology, Liaoning Normal University, Dalian 116023, Liaoning Province, China
    4 School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning Province, China
  • Received:2013-02-16 Revised:2013-08-26 Online:2013-10-15 Published:2013-10-15
  • Contact: Jing Liu, M.D., Professor, Regenerative Medicine Center, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning Province, China, liujing.dlrmc@hotmail.com.
  • About author:Yang Liu, M.D., Lecturer. Yang Liu and Zhanhua Liang contributed equally to this paper.

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摘要：

窖蛋白（caveolin-1）参与调节突触可塑性，但其表达与衰老后的认知功能的关系还存在争议。为探索在衰老过程中突触可塑性和学习记忆能力变化的关系，实验观察不同年龄大鼠海马、皮质和小脑caveolin-1的表达，及其与突触可塑性的标记物突触素表达的关系。结果显示与年轻（1个月龄）及成年（4个月龄）大鼠相比，老龄(24个月龄)大鼠海马中Caveolin-1和突触素表达明显下降，而皮质中Caveolin-1和突触素表达明显增加，且不同年龄大鼠小脑中caveolin-1与突触素表达水平接近。线性回归分析显示大鼠海马中突触素的表达与记忆能力有关，且大鼠海马、皮质和小脑中caveolin-1和突触素表达水平呈正相关。证实caveolin-1在调节突触可塑性方面的作用，且在生理老化过程中海马caveolin-1表达下调可能突触可塑性的降低。

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