中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (31): 2951-2961.doi: 10.3969/j.issn.1673-5374.2013.31.008

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

健康成年恒河猴脑的弥散张量成像特点

  

  • 收稿日期:2012-12-03 修回日期:2013-03-27 出版日期:2013-11-05 发布日期:2013-11-05
  • 基金资助:

    国家自然科学基金(No30960398，No81260213);中国博士后科学基金第四十七批面上资助(No20100470376); 云南省自然科学基金资助项目(No.2009cd1178)

Characteristics of diffusion-tensor imaging for healthy adult rhesus monkey brains

Xinxiang Zhao1, Jun Pu2, Yaodong Fan3, Xiaoqun Niu4, Danping Yu5, Yanglin Zhang1   

  1. 1 Department of Radiology, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China
    2 Department of Neurosurgery, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China
    3 Department of Neurosurgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650106, Yunnan Province, China
    4 Department of Pneumology, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China
    5 Yiwu Hospital Affiliated to Zhejiang University School of Medicine, Yiwu 322001, Zhejiang Province, China
  • Received:2012-12-03 Revised:2013-03-27 Online:2013-11-05 Published:2013-11-05
  • Contact: Jun Pu, M.D., Associate chief physician, Department of Neurosurgery, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China, pujun303@yahoo com.cn; zhaoxinxiang06@ 126.com.
  • About author:Xinxiang Zhao, M.D., Associate chief physician.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 30960398, 81260213; the Forty-Seventh Batch of China Postdoctoral Science Foundation, No. 20100470376.

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摘要：

磁共振弥散张量成像可观测脑组织微观结构，各向异性分数值能够反映脑白质纤维的完整性。健康青壮年人脑各向异性分数值，灰质较低，白质较高，白质中以胼胝体压部为最高。鉴于此，利用磁共振弥散张量成像观察4-8岁健康恒河猴脑主要白质纤维束和深部灰质的各向异性分数值，感兴趣区选择了内囊前肢、后肢、尾状核头、半卵圆中心、丘脑、胼胝体体部和压部。结果显示，恒河猴双侧同一部位感兴趣区各向异性分数值无偏侧性差异，灰质如尾状核头和丘脑各向异性分数值较低，白质中胼胝体压部最高，其次为胼胝体膝部和内囊后肢，然后为半卵圆区、内囊后肢。结果说明，健康4-8岁恒河猴脑主要白质纤维束和深部灰质各向异性分数值与健康青壮年人类似。

关键词: 神经再生, 神经影像, 恒河猴, 各向异性分数, 脑, 白质, 灰质, 磁共振, 弥散张量成像, 基金资助文章

Abstract:

Diffusion-tensor imaging can be used to observe the microstructure of brain tissue. Fractional ani-sotropy reflects the integrity of white matter fibers. Fractional anisotropy of a young adult brain is low in gray matter, high in white matter, and highest in the splenium of the corpus callosum. Thus, we selected the anterior and posterior limbs of the internal capsule, head of the caudate nucleus, semioval center, thalamus, and corpus callosum (splenium and genu) as regions of interest when using diffusion-tensor imaging to observe fractional anisotropy of major white matter fiber tracts and the deep gray matter of healthy rhesus monkeys aged 4–8 years. Results showed no laterality dif-ferences in fractional anisotropy values. Fractional anisotropy values were low in the head of cau-date nucleus and thalamus in gray matter. Fractional anisotropy values were highest in the splenium of corpus callosum in the white matter, followed by genu of the corpus callosum and the posterior limb of the internal capsule. Fractional anisotropy values were lowest in the semioval center and posterior limb of internal capsule. These results suggest that fractional anisotropy values in major white matter fibers and the deep gray matter of 4–8-year-old rhesus monkeys are similar to those of healthy young people.

Key words: neural regeneration, neuroimaging, rhesus monkey, fractional anisotropy, brain, white matter, gray matter, MRI, diffusion-tensor imaging, grants-supported paper, neuroregeneration