中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (35): 3344-3352.doi: 10.3969/j.issn.1673-5374.2013.35.009

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

正常人不确定奖赏抉择加工激活脑区的分析

  

  • 收稿日期:2013-07-24 修回日期:2013-07-24 出版日期:2013-12-15 发布日期:2013-12-15
  • 基金资助:

    山东省科技发展计划项目（2011YD18045）；山东省自然科学基金项目（ZR2012HM049）；山东省保健基金资助项目(2007BZ19)；青岛市科技局基金资助项目（Kzd-03；09-1-1-33-nsh）。

Brain areas activated by uncertain reward-based decision-making in healthy volunteers

Zongjun Guo1, 2, Juan Chen1, 2, Shien Liu2, 3, Yuhuan Li4, Bo Sun4, Zhenbo Gao4   

  1. 1 Special Health Care Department, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
    2 The Institute of Brain Science & Human Resource Management of Qingdao University, Qingdao 266003, Shandong Province, China
    3 Department of Medical Imaging, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
    4 Qingdao Mental Health Center, Qingdao 266034, Shandong Province, China
  • Received:2013-07-24 Revised:2013-07-24 Online:2013-12-15 Published:2013-12-15
  • Contact: Zongjun Guo, M.D., Chief physician, Professor, Special Health Care Department, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China; the Institute of Brain Science & Human Resource Management of Qingdao University, Qingdao 266003, Shandong Province, China, guozjj@163.com. Shien Liu, Master, Attending physician, the Institute of Brain Science & Human Resource Management of Qingdao University, Qingdao 266003, Shandong Province, China; Department of Medical Imaging, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China, shien_28@126.com.
  • Supported by:

    This study was supported by the Science and Technology Development Project of Shandong Province, China, No. 2011YD18045; the Natural Science Foundation of Shandong Province, China, No. ZR2012HM049; the Health Care Foundation Program of Shandong Province, China, No. 2007BZ19; the Foundation Program of Technology Bureau of Qingdao, China; No. Kzd-03; 09-1-1-33-nsh.

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摘要：

研究发现与奖赏抉择有关的脑区有腹外侧前额叶、眶额叶、前扣带回、腹侧纹状体以及多巴胺中脑区域等。实验在此基础上观察确定、风险、含糊3种不同程度奖赏抉择加工的激活脑区。实验应用脑功能视听觉刺激系统呈现任务，以3.0 T磁共振对15名健康受试者进行大脑同步扫描，采用SPM8分析获得3种不同程度奖赏抉择刺激下相关激活脑区和激活强度值。结果发现确定奖赏抉择时眶额叶被激活；风险奖赏抉择时前额叶、中央前回、枕叶联合视皮质、顶下小叶、小脑后叶、颞中回、颞下回、边缘叶及中脑被激活；含糊奖赏抉择时前额叶、颞极区及颞下回、枕叶视皮质、小脑后叶被激活。可见不确定性奖赏程度不同，参与加工的脑区存在显著差异，随着奖赏不确定程度的增高，激活脑区的数量增加，代表损失意义加工的脑区也出现激活增多。

中国神经再生研究（英文版）杂志出版内容重点： 脑损伤；脊髓损伤；周围神经损伤；帕金森；神经影像；神经再生

关键词: 神经再生, 神经影像, 决策, 奖赏, 不确定, 认知加工, 功能磁共振, 脑, 基金资助文章

Abstract:

Reward-based decision-making has been found to activate several brain areas, including the ventrolateral prefrontal lobe, orbitofrontal cortex, anterior cingulate cortex, ventral striatum, and mesolimbic dopaminergic system. In this study, we observed brain areas activated under three de-grees of uncertainty in a reward-based decision-making task (certain, risky, and ambiguous). The tasks were presented using a brain function audiovisual stimulation system. We conducted brain scans of 15 healthy volunteers using a 3.0T magnetic resonance scanner. We used SPM8 to ana-lyze the location and intensity of activation during the reward-based decision-making task, with re-spect to the three conditions. We found that the orbitofrontal cortex was activated in the certain reward condition, while the prefrontal cortex, precentral gyrus, occipital visual cortex, inferior parietal lobe, cerebellar posterior lobe, middle temporal gyrus, inferior temporal gyrus, limbic lobe, and midbrain were activated during the ‘risk’ condition. The prefrontal cortex, temporal pole, inferior temporal gyrus, occipital visual cortex, and cerebellar posterior lobe were activated during ambig-uous decision-making. The ventrolateral prefrontal lobe, frontal pole of the prefrontal lobe, orbito-frontal cortex, precentral gyrus, inferior temporal gyrus, fusiform gyrus, supramarginal gyrus, inferior parietal lobule, and cerebellar posterior lobe exhibited greater activation in the ‘risk’ than in the ‘certain’ condition (P < 0.05). The frontal pole and dorsolateral region of the prefrontal lobe, as well as the cerebellar posterior lobe, showed significantly greater activation in the ‘ambiguous’ condition compared to the ‘risk’ condition (P < 0.05). The prefrontal lobe, occipital lobe, parietal lobe, temporal lobe, limbic lobe, midbrain, and posterior lobe of the cerebellum were activated during deci-sion-making about uncertain rewards. Thus, we observed different levels and regions of activation for different types of reward processing during decision-making. Specifically, when the degree of reward uncertainty increased, the number of activated brain areas increased, including greater ac-tivation of brain areas associated with loss.

Key words: neural regeneration, neuroimaging, decision-making, reward, uncertainty, cognitive processing, functional magnetic resonance imaging, brain, grants-supported paper, neuroregeneration