中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (36): 3441-3448.doi: 10.3969/j.issn.1673-5374.2013.36.010
负载人脐带间充质干细胞的羊膜移植修复桡神经损伤
Human umbilical cord mesenchymal stem cell-loaded amniotic membrane for the repair of radial nerve injury
Zhi Li1, Hanjiao Qin2, Zishan Feng3, Wei Liu1, Ye Zhou1, Lifeng Yang1, Wei Zhao1, Youjun Li4
- 1 Affiliated Central Hospital of Shenyang Medical College, Shenyang 110024, Liaoning Province, China
2 Department of Endocrinology and Metabolism, First Clinical Hospital of Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China
3 Shengjing Hospital, China Medical University, Shenyang 110000, Liaoning Province, China
4 Department of Human Anatomy and Histoembryology, Norman Bethune University of Medical Science, Changchun 130000, Jilin Province, China
摘要：
实验将人脐带间充质干细胞负载于非去上皮细胞的人羊膜上制成神经导管，形成相对密闭的神经再生室。并于桡神经损伤20例患者行探查松解损伤神经后，将该神经导管包覆于神经损伤处，并用缝线固定在神经外膜上，细胞面在内侧。并在神经损伤处的远、近端分别间隔1.0cm注入人脐带间充质干细胞悬液1.0mL，移植细胞总数1.75×107。以单纯行探查松解损伤神经者为对照组。移植后第12周，80%以上的患者肌力、触觉以及疼痛感觉较移植前明显改善；而对照组该比例则只为55%-65%。移植后第8和12周，患者损伤桡神经支配区域的肌肉电生理功能明显好于对照组。移植后未见排斥反应。以上数据提示，负载人脐带间充质干细胞的人羊膜可用于修复桡神经损伤。 中国神经再生研究（英文版）杂志出版内容重点： 脑损伤；脊髓损伤；周围神经损伤；帕金森；神经影像；神经再生
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