中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (23): 2081-2086.doi: 10.4103/1673-5374.147935

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

无偏瘫性完全失语症特异性损伤病灶:脑MRI重叠技术首次定位在相关脑区

  

  • 收稿日期:2014-10-28 出版日期:2014-12-10 发布日期:2014-12-10

Lesion localization of global aphasia without hemiparesis by overlapping of the brain magnetic resonance images

Woo Jin Kim 1, 2, Nam-Jong Paik 1, 3   

  1. 1 Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea
    2 Department of Physical Medicine and Rehabilitation, Haeundae Paik Hospital, Inje University of Medicine, Busan, South Korea
    3 Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, South Korea
  • Received:2014-10-28 Online:2014-12-10 Published:2014-12-10
  • Contact: Nam-Jong Paik, M.D., Ph.D., Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, South Korea, njpaik@snu.ac.kr.
  • Supported by:

    This study was supported by a grant from the Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea, No. A101901.

摘要:

无偏瘫性完全失语症表现为无对侧偏瘫的语言功能缺损,其常发生于左侧的外侧裂周区大面积损害后。我们回顾性分析了脑MRI检查到的6例无偏瘫性完全失语症患者大脑特异性损害病灶。3例以上患者MRI病灶重叠视为有意义。6例患者失语症相关的脑卒中病灶主要定位于额叶、下回、下叶、外核、胼胝体、额下回。研究首次通过MRI重叠技术证实了无偏瘫性完全失语症在不同脑区的特异性损害病灶。

关键词: 神经再生, 无偏瘫性完全失语症, 全面性失语, 脑卒中, 偏瘫, 大脑, MRI, MRI重叠

Abstract:

Global aphasia without hemiparesis is a striking stroke syndrome involving language impairment without the typically manifested contralateral hemiparesis, which is usually seen in patients with global aphasia following large left perisylvian lesions. The objective of this study is to elucidate the specific areas for lesion localization of global aphasia without hemiparesis by retrospectively studying the brain magnetic resonance images of six patients with global aphasia without hemiparesis to define global aphasia without hemiparesis-related stroke lesions before overlapping the images to visualize the most overlapped area. Talairach coordinates for the most overlapped areas were converted to corresponding anatomical regions. Lesions where the images of more than three patients overlapped were considered significant. The overlapped global aphasia without hemiparesis related stroke lesions of six patients revealed that the significantly involved anatomical lesions were as follows: frontal lobe, sub-gyral, sub-lobar, extra-nuclear, corpus callosum, and inferior frontal gyrus, while caudate, claustrum, middle frontal gyrus, limbic lobe, temporal lobe, superior temporal gyrus, uncus, anterior cingulate, parahippocampal, amygdala, and subcallosal gyrus were seen less significantly involved. This study is the first to demonstrate the heterogeneous anatomical involvement in global aphasia without hemiparesis by overlapping of the brain magnetic resonance images.

Key words: nerve regeneration, global aphasia without hemiparesis, global aphasia, stroke, hemiparesis, brain, magnetic resonance imaging, neural regeneration