中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1892-1896.doi: 10.4103/1673-5374.170325

• 综述:脑损伤修复保护与再生 • 上一篇    

抑制中枢神经轴突再生的重要途径:Ras同源基因-Rho相关螺旋卷曲蛋白激酶信号通路

  

  • 收稿日期:2015-06-17 出版日期:2015-12-07 发布日期:2015-12-07
  • 基金资助:

    国家自然科学基金资助项目(81471087, 81170577)

The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system

Jing Liu1, *, Hong-yan Gao1, Xiao-feng Wang1, 2   

  1. 1 Department of Neonatology & NICU of Bayi Children’s Hospital, General Hospital of Beijing Military Command of Chinese PLA, Beijing, China
    2 Department of Neonatology, People’s Hospital of Rizhao, Rizhao, Shangdong Province, China
  • Received:2015-06-17 Online:2015-12-07 Published:2015-12-07
  • Contact: Jing Liu, M.D., liujingbj@live.cn.
  • Supported by:

    This research was supported by a grant from the National Natural Science Foundation of China, No. 81471087, 81170577.

摘要:

Ras同源基因-Rho相关螺旋卷曲蛋白激酶信号途径是中枢神经系统中普遍存在的一条通路,是介导抑制性信号阻断中枢神经细胞再生的重要途径之一。中枢神经损伤后再生困难的重要原因是其周围环境中存在强烈抑制再生的物质,这些物质可通过Ras同源基因-Rho相关螺旋卷曲蛋白激酶途径介导神经再生障碍。因而,熟悉Ras同源基因-Rho相关螺旋卷曲蛋白激酶信号通路的作用,对中枢神经损伤后再生与修复的认知与研究具有重要意义。

关键词: 神经再生, Ras同源基因-Rho相关螺旋卷曲蛋白激酶, 信号通路, 轴突再生, 中枢神经系统, 微环境, 综述

Abstract:

The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous system damage, the main cause of impaired regeneration is the presence of factors that strongly inhibit regeneration in the surrounding microenvironment. These factors signal through the Rho/ROCK signaling pathway to inhibit regeneration. Therefore,
a thorough understanding of the Rho/ROCK signaling pathway is crucial for advancing studies on regeneration and repair of the injured central nervous system.

Key words: nerve regeneration, Rho/Rho-associated coiled-coil containing protein kinase, signaling pathway, axonal regeneration, central nervous system, microenvironment, reviews, NSFC grant, neural regeneration