中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (10): 1666-1669.doi: 10.4103/1673-5374.193248

• 原著:颅神经损伤修复保护与再生 • 上一篇    下一篇

电刺激对犬损伤动眼神经再生的作用

  

  • 收稿日期:2016-09-12 出版日期:2016-10-31 发布日期:2016-10-31
  • 基金资助:
    中国国家自然科学基金项目(30571907);上海市科委国际科技合作基金项目(10410711400)

Electrical stimulation promotes regeneration of injured oculomotor nerves in dogs

Lei Du1, Min Yang2, Liang Wan2, Xu-hui Wang2, Shi-ting Li2, *   

  1. 1 Department of Gerontology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 Department of Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  • Received:2016-09-12 Online:2016-10-31 Published:2016-10-31
  • Contact: Shi-ting Li, M.D., Lsting66@163.com.
  • Supported by:
    This study was supported by a grant from the National Natural Science Foundation of China, No. 30571907; the International Science and Technology Cooperation Foundation of the Shanghai Committee of Science and Technology, China, No. 10410711400.

摘要:

动眼神经功能障碍修复后功能恢复效果较差,研究显示电刺激对损伤神经的再生具有促进作用。为此,实验假设电刺对损伤的动眼神经也有促进功能恢复的效果。在成年犬右侧动眼神经行机械卡压损伤造模,将刺激电极分别固定在损伤动眼神经断端两侧,使其接受非连续矩形双向脉冲0.7 V、5Hz电流刺激1h/d,连续2周接受电刺激治疗。见犬损伤动眼神经调控部位的电生理活动得到恢复,神经组织形态也有一定恢复,说明电刺激可促进损伤动眼神经再生的过程,成为治疗动眼神经损伤潜在的可继续深入研究和开发的疗法。 

orcid: 0000-0001-9133-5874 (Shi-ting Li)

关键词: 神经再生, 动眼神经, 电刺激, 犬, 神经损伤, 脑神经, 周围神经

Abstract: Functional recovery afer oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the right oculomotor nerves of adult dogs. Stimulating electrodes were positioned in both proximal and distal locations of the lesion, and non-continuous rectangular, biphasic current pulses (0.7 V, 5 Hz) were administered 1 hour daily for 2 consecutive weeks. Analysis of the results showed that electrophysiological and morphological recovery of the injured oculomotor nerve was enhanced, indicating that electrical stimulation improved neural regeneration. Tus, this therapy has the potential to promote the recovery of oculomotor nerve dysfunction.

Key words: nerve regeneration, oculomotor nerve, electrical stimulation, dog, nerve injury, model, cranial nerve, peripheral nerve