中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (9): 1551-1558.doi: 10.4103/1673-5374.215268

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

有髓鞘轴突中接触蛋白相关蛋白家族的生成、结构和功能及与神经疾病的关系

  

  • 收稿日期:2017-06-10 出版日期:2017-09-15 发布日期:2017-09-15
  • 基金资助:

     

    无锡市卫计委教学项目(0302B010507130039PB

Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases

Yan Zou, Wei-feng Zhang, Hai-ying Liu, Xia Li, Xing Zhang, Xiao-fang Ma, Yang Sun, Shi-yi Jiang, Quan-hong Ma, De-en Xu   

  1. Department of Neurology, The Second People’s Hospital of Wuxi, Wuxi, Jiangsu Province, China
  • Received:2017-06-10 Online:2017-09-15 Published:2017-09-15
  • Contact: De-en Xu, Ph.D.,xudeen@126.com.
  • Supported by:

    This study was supported by a grant from the Instructional Program of Science and Technology Bureau of Wuxi City of China, No.0302B010507130039PB.

摘要:

既往研究显示接触蛋白相关蛋白家族参与有髓鞘的轴突中神经兴奋传导、神经递质释放等功能。作者就接触蛋白相关蛋白家族的生成、结构和功能进行分析,总结发现接触蛋白相关蛋白家族Caspr1-5,不仅参与有髓鞘的轴突的形成,而且参与维持节旁连接的稳定。有大量研究显示接触蛋白相关蛋白还参与神经元和星形胶质细胞的生成、分化和增殖,以及运动控制和认知功能。文章还就接触蛋白相关蛋白家族与神经退行性疾病、多发性硬化和自身免疫性脑炎等疾病的关系进行分析,但蛋白对疾病病程和预后的作用仍不明确,还需进一步研究其在疾病诊断治疗中的作用。

orcid:0000-0001-9718-8457(De-en Xu)

关键词: 神经再生, 接触蛋白相关蛋白家族, 有髓轴轴突, 结构, 功能, 阿尔茨海默病, 多发性硬化症, 自闭症, 神经退行性疾病

Abstract:

The contactin-associated protein (Caspr) family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family–CNTNAP1 (Caspr1), CNTNAP2 (Caspr2), CNTNAP3 (Caspr3), CNTNAP4 (Caspr4) and CNTNAP5 (Caspr5), Caspr1–5 is not only involved in the formation of myelinated axons, but also participates in maintaining the stability of adjacent connections. Caspr1 participates in the formation, differentiation, and proliferation of neurons and astrocytes, and in motor control and cognitive function. We also analyzed the relationship between the Caspr family and neurodegenerative diseases, multiple sclerosis, and autoimmune encephalitis. However, the effects of Caspr on disease course and prognosis remain poorly understood. The effects of Caspr on disease diagnosis and treatment need further investigation.

Key words: nerve regeneration, contactin-associated protein family, myelinated axon, structure, function, Alzheimer’s disease, multiple sclerosis, autism spectrum disorders, neurodegeneration, neural regeneration