中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1335-1342.doi: 10.4103/1673-5374.253510

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

巨噬细胞参与周围神经损伤的修复

  

  • 出版日期:2019-08-15 发布日期:2019-08-15
  • 基金资助:

    中国国家自然科学基金项目(31771052);国家重点研究发展计划项目(2017YFA0104701,2017YFA0104702,2016YFC1101601);国家重点基础研究发展计划(2014CB542201);北京市自然科学基金项目(7172202);解放军医学青年培养项目(16QNP144)

Role of macrophages in peripheral nerve injury and repair

Ping Liu 1, 2 , Jiang Peng 2 , Gong-Hai Han 3 , Xiao Ding 4 , Shuai Wei 4 , Gang Gao 5 , Kun Huang 6 , Feng Chang 5 , Yu Wang 2   

  1. 1 Shanxi Medical University, Taiyuan, Shanxi Province, China
    2 Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China
    3 Kunming Medical University, Kunming, Yunnan Province, China
    4 Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region, China
    5 Department of Orthopaedic Surgery, Shanxi Provincial People’s Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China
    6 Anhui Medical University Air Force Clinical College, Hefei, Anhui Province, China
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Feng Chang, BS, cfmedmail@163.com; Yu Wang, PhD, wangwangdian628@126.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 31771052 (to YW); the National Key Research & Development Program of China, No. 2017YFA0104701, 2017YFA0104702 and 2016YFC1101601; the National Basic Research Program of China (973 Program), No. 2014CB542201 (to JP); the Natural Science Foundation of Beijing, No. 7172202 (to YW); and the PLA Youth Training Project for Medical Science, No. 16QNP144 (to YW).

摘要:

巨噬细胞分为常驻和炎症巨噬细胞,都是先天免疫系统的重要效应细胞,这些细胞参与先天免疫防御,并调节组织和器官的体内平衡。除了参与癌症、肥胖和骨关节炎等疾病,常驻和炎症巨噬细胞还在组织修复和疾病康复中发挥重要的作用。巨噬细胞和其他炎症细胞能被募集到组织损伤部位,并促进损伤部位微环境的改变。在所有炎性细胞中,只有巨噬细胞具有促炎(M1)和抗炎(M2)作用,其中M2巨噬细胞有4种亚型。当M1和M2巨噬细胞共同作用时,可以产生有利于组织修复的微环境,并释放细胞因子参与组织修复。此次综述还讨论了巨噬细胞激活及其在严重周围神经损伤的作用,同时探索了巨噬细胞在神经组织工程治疗中的潜力,以及增强M2细胞介导的神经修复或再生的方法。

orcid: 0000-0001-7811-5834 (Yu Wang)

关键词: 巨噬细胞, 起源, 极化, 功能, 神经损伤, 神经修复, 组织工程, 神经再生

Abstract:

Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and organ homeostasis. In addition to their roles in diseases such as cancer, obesity and osteoarthritis, they play vital roles in tissue repair and disease rehabil¬itation. Macrophages and other inflammatory cells are recruited to tissue injury sites where they promote changes in the microenvironment. Among the inflammatory cell types, only macrophages have both pro-inflammatory (M1) and anti-inflammatory (M2) actions, and M2 macrophages have four subtypes. The co-action of M1 and M2 subtypes can create a favorable microenvironment, releasing cytokines for damaged tissue repair. In this review, we discuss the activation of macrophages and their roles in severe pe¬ripheral nerve injury. We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated nerve repair and regeneration.

Key words: nerve regeneration, macrophage, origin, polarization, function, nerve injury, nerve repair, tissue engineering, neural regeneration