中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (11): 2269-2275.doi: 10.4103/1673-5374.310693

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

大鼠、山羊和人类体感诱发电位时频成分间的转化研究

  

  • 出版日期:2021-11-15 发布日期:2021-04-13
  • 基金资助:

    国家自然科学基金项目（81871768），天津市自然科学基金项目（18JCYBJC29600），广东省卫健会高水平医院项目（HKUSZH201902011）

A translational study of somatosensory evoked potential time–frequency components in rats, goats, and humans

Hong-Yan Cui, Yi-Xin Wu, Rong Li, Guang-Sheng Li, Yong Hu   

  1. 1Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; 2Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong Special Administrative Region, China; 3Spinal Division, Department of Orthopaedics, Affiliated Hospital of Guangdong Medical University, Guangdong Province, China; 4Department of Orthopaedics and Traumatology, The University of Hong Kong -Shenzhen Hospital, Shenzhen, Guangdong Province, China
  • Online:2021-11-15 Published:2021-04-13
  • Contact: Yong Hu, PhD, yhud@hku.hk.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81871768 (to YH); the Natural Science Foundation of Tianjin of China, No. 18JCYBJC29600 (to HYC); and High Level-Hospital Program, Health Commission of Guangdong Province of China, No. HKUSZH201902011 (to YH).

PDF

104

摘要：

体感诱发电位已广泛用于临床评估体感通路的完整性，对体感诱发电位信号与神经功能关系的了解是精确诊断的基础，既往体感诱发电位的研究主要基于动物实验模型，尚无系统地分析动物和人类之间体感诱发电位信号的关系。此次实验收集了人类、SD大鼠以及山羊的正常体感诱发电位信号，然后将其分解为特定的时频成分。（1）在正常情况下，动物和人类的体感诱发电位均有3个稳定时频成分分布区域。而脊髓损伤后，山羊和大鼠出现更多小TFC。人、山羊和大鼠体感诱发电位的主要时频成分之间存在显著相关性和线性关系；（2）人、大鼠和山羊的体感诱发电位均存在稳定的时频成分，并呈相似的时频分布模式。人体实验已于2005年12月5日经香港大学及医管局港岛西医院联网研究伦理委员会批准（批准号UM 05-312 T / 975）；大鼠实验于2013年1月28日经香港大学李嘉诚医学院动物伦理委员会批准（批准号CULART 2912-12）；山羊实验于2018年3月5日广东医科大学附属医院动物伦理委员会批准（批准号GDY2002132）。

https://orcid.org/0000-0003-0305-5616 (Yong Hu)

关键词:

体感诱发电位, 潜伏期, 时频分析, 时频成分, 动物模型, 脊髓损伤, 慢性压迫, 转化研究

Abstract: Somatosensory evoked potentials (SEPs) have been widely used to assess neurological function in clinical practice. A good understanding of the association between SEP signals and neurological function is helpful for precise diagnosis of impairment location. Previous studies on SEPs have been reported in animal models. However, few studies have reported the relationships between SEP waveforms in animals and those in humans. In this study, we collected normal SEP waveforms and decomposed them into specific time–frequency components (TFCs). Our results showed three stable TFC distribution regions in intact goats and rats and in humans. After we induced spinal cord injury in the animal models, a greater number of small TFC distribution regions were observed in the injured goat and rat groups than in the normal group. Moreover, there were significant correlations (P < 0.05) and linear relationships between the main SEP TFCs of the human group and those of the goat and rat groups. A stable TFC distribution of SEP components was observed in the human, goat and rat groups, and the TFC distribution modes were similar between the three groups. Results in various animal models in this study could be translated to future clinical studies based on SEP TFC analysis. Human studies were approved by the Institutional Review Board of the University of Hong Kong/Hospital Authority Hong Kong West Cluster (approval No. UM 05-312 T/975) on December 5, 2005. Rat experiments were approved by the Committee on the Use of Live Animals in Teaching and Research of Li Ka Shing Faculty of Medicine of the University of Hong Kong (approval No. CULART 2912-12) on January 28, 2013. Goat experiments were approved by the Animal Ethics Committee of Affiliated Hospital of Guangdong Medical University (approval No. GDY2002132) on March 5, 2018.

Key words: animal models, chronic compression, latency, somatosensory evoked potentials, spinal cord injury, time–frequency analysis, time–frequency components, translational study

中图分类号: