中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (10): 2175-2188.doi: 10.4103/1673-5374.391308

• 综述:退行性病与再生 • 上一篇    下一篇

运动干预与阿尔茨海默病

  

  • 出版日期:2024-10-15 发布日期:2024-01-29
  • 基金资助:
    了国家自然科学基金项目(81971309,32170980,82260272);江西省自然科学基金项目(20192BAB205078);广东省基础与应用基础研究基金项目(2022B1515020012);深圳市基础研究计划项目(JCYJ20210324123212035,RCYX20200714114644167,ZDSYS20220606100801003

Efficacy of exercise rehabilitation for managing patients with Alzheimer’s disease

Dan Li1, Jinning Jia1, Haibo Zeng2, Xiaoyan Zhong1, Hui Chen3, Chenju Yi4, 5, 6, *   

  1. 1Department of Pathology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China; 2Department of Pathology, Huichang County People’s Hospital, Ganzhou, Jiangxi Province, China; 3School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia; 4Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong Province, China; 5Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research, Shenzhen, Guangdong Province, China; 6Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong Province, China
  • Online:2024-10-15 Published:2024-01-29
  • Contact: Chenju Yi, MD, PhD, yichj@mail.sysu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 81971309 (to CY), 32170980 (to CY), 82260272 (to DL); the Natural Science Foundation of Jiangxi Province, No. 20192BAB205078 (to DL); Guangdong Basic and Applied Basic Research Foundation, No. 2022B1515020012 (to CY); and Shenzhen Fundamental Research Program, Nos. JCYJ20210324123212035 (to CY), RCYX20200714114644167 (to CY), and ZDSYS20220606100801003 (to CY).

摘要:

阿尔茨海默病是一种以认知功能恶化为特征的进行性和退行性神经系统疾病。虽然目前还没有有效的治疗方法能阻止阿尔茨海默病进展,但大量研究提出运动治疗阿尔茨海默病的潜在优势。运动能显著改善阿尔茨海默病患者认知功能和生活质量。因此,运动干预被认为是阿尔茨海默病患者管理最重要的策略之一。此次综述对目前阿尔茨海默病患者运动康复的研究进展进行了全面分析,重点是不同类型运动单独或与其他治疗方法联合的疗效及运动如何改善大脑微环境和神经元可塑性。文章结果将有助于临床中针对阿尔茨海默病患者制定更有效、更精细的运动疗法,特别是在中低收入国家。

https://orcid.org/0000-0002-8686-4525 (Chenju Yi)

关键词: 阿尔茨海默病, 运动, 认知功能, 脑血管功能, 神经可塑性, 海马神经发生, 神经炎症, 线粒体, 表观遗传调控

Abstract: Alzheimer’s disease (AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low- and middle-income countries.

Key words: Alzheimer’s disease, cerebrovascular function, cognitive function, epigenetic regulation, exercise, hippocampal neurogenesis, mitochondria, neuroinflammation, neuronal plasticity