中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (18): 1703-1708.doi: 10.4103/1673-5374.141807

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

颅脑损伤可促进损伤周围神经的修复

  

  • 收稿日期:2014-06-19 出版日期:2014-09-26 发布日期:2014-09-26
  • 基金资助:

    河北省科技厅课题(142777105D, 13277772D)

Craniocerebral injury promotes the repair of peripheral nerve injury

Wei Wang 1, Jun Gao 2, Lei Na 2, Hongtao Jiang 2, Jingfeng Xue 3, Zhenjun Yang 3, Pei Wang 1   

  1. 1 Department of Hand and Foot Surgery, Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China
    2 Department of Postgraduate, Chengde Medical College, Chengde, Hebei Province, China
    3 Department of Anatomy, Chengde Medical College, Chengde, Hebei Province, China
  • Received:2014-06-19 Online:2014-09-26 Published:2014-09-26
  • Contact: Pei Wang, Department of Hand and Foot Surgery, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China, cdgkwp@sina.com.
  • Supported by:

    This study was supported by a grant from Hebei Provincial Science and Technology Department in China, No. 142777105D, 13277772D.

摘要:

研究表明颅脑损伤后体内增多的神经营养因子是促进骨折愈合的原因之一,且神经营养因子对周围神经的再生与修复起重要的作用,但颅脑损伤是否也能对周围神经的损伤修复产生影响,尚不可知。实验采用自由落体装置建立颅脑损伤模型后,横断大鼠左侧坐骨神经,结果发现损伤后6-12周,与单纯坐骨神经损伤大鼠相比,颅脑损伤合并坐骨神经损伤大鼠坐骨神经功能指数降低,腓肠肌湿重恢复率较高,坐骨神经神经节及相应脊髓节段神经元形态明显恢复,且辣根过氧化物标记细胞明显增多。提示颅脑损伤在一定程度上对损伤周围神经修复具有促进效应。

关键词: 神经再生, 颅脑损伤, 周围神经, 坐骨神经, 坐骨神经损伤, 神经修复, 辣根过氧化物示踪技术

Abstract:

The increase in neurotrophic factors after craniocerebral injury has been shown to promote fracture healing. Moreover, neurotrophic factors play a key role in the regeneration and repair of peripheral nerve. However, whether craniocerebral injury alters the repair of peripheral nerve injuries remains poorly understood. Rat injury models were established by transecting the left sciatic nerve and using a free-fall device to induce craniocerebral injury. Compared with sciatic nerve injury alone after 6–12 weeks, rats with combined sciatic and craniocerebral injuries showed decreased sciatic functional index, increased recovery of gastrocnemius muscle wet weight, recovery of sciatic nerve ganglia and corresponding spinal cord segment neuron morphologies, and increased numbers of horseradish peroxidase-labeled cells. These results indicate that craniocerebral injury promotes the repair of peripheral nerve injury.

Key words: nerve regeneration, craniocerebral injury, peripheral nerve, sciatic nerve, sciatic nerve injury, nerve repair, horseradish peroxidase tracer technique, neural regeneration