中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (11): 1845-1850.doi: 10.4103/1673-5374.259601

• 综述:视神经损伤修复保护与再生 •    下一篇

正常眼压性青光眼：从脑到眼亦或相反？

  

  • 出版日期:2019-11-15 发布日期:2019-11-15
  • 基金资助:

    国家基础研究计划项目（81300766），暨南大学第一附属医院培养创新基金（802168），广东省领军人才基金项目（87014002），宁夏重点研究发展项目，高校引进人才培养方案（B14036）

Normal tension glaucoma: from the brain to the eye or the inverse?

Hui-Jun Zhang 1, Xue-Song Mi 1 , Kwok-Fai So 2, 3, 4   

  1. 1 Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China
    2 Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China
    3 State Key Laboratory of Brain and Cognitive Sciences, Pokfulam, Hong Kong Special Administrative Region, China
    4 Department of Ophthalmology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
  • Online:2019-11-15 Published:2019-11-15
  • Contact: Xue-Song Mi, PhD, mxsong@163.com; Kwok-Fai So, PhD, hrmaskf@hku.hk.
  • Supported by:

    This study was supported in part by the National Basic Research Program of China, No. 81300766 (to XSM); the Cultivation and Innovation Fund from the First Affiliated Hospital of Jinan University, China, No. 802168 (to XSM); the fund of Leading Talents of Guangdong Province, China, No. 87014002 (to KFS); the fund of Ningxia Key Research and Development Program (Yinchuan, Ningxia Hui Autonomous Region, China), and Programme of Introducing Talents of Discipline to Universities, China, No. B14036 (to KFS).

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摘要：

青光眼是一种慢性进行性复杂的视神经病变，其特征是先周边视力丧失后中央视力丧失。正常眼压性青光眼临床上被视为一种特殊类型的青光眼，其患者眼压处于正常范围值内，但却表现出典型的青光眼性改变。对基于眼压正常青光眼传统病理生理学观点受到越来越多证据的挑战。目前，中枢神经系统成像技术的突破可能打破对正常眼压性青光眼传统发病机制的认识瓶颈。此次综述将回顾正常眼压性青光眼的发病机制和成像技术的最新进展，有助于进一步探索正常眼压性青光眼的发病与大脑之间的关系。

orcid: 0000-0002-8566-9277(Marta Agudo-Barriuso)

关键词: 正常眼压性青光眼, 广角性青光眼, 神经退行性疾病, 脑, 脑脊液压力, 成像技术, 发病, 磁共振成像, 弥散张量成像, 代谢变化, 神经再生

Abstract:

Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in which the patient’s intraocular pressure is within the normal range, but the patient experiences typical glaucomatous changes. However, increasing evidence has challenged the traditional pathophysiological view of normal tension glaucoma, which is based only on intraocular pressure, and breakthroughs in central nervous system imaging may now greatly increase our knowledge about the mechanisms underlying normal tension glaucoma. In this article, we review the latest progress in understanding the pathogenesis of normal tension glaucoma and in developing imaging techniques to detect it, to strengthen the appreciation for the connection between normal tension glaucoma and the brain.

Key words: nerve regeneration, normal tension glaucoma, open angle glaucoma, neurodegenerative diseases, visual field, cerebrospinal fluid pressure, imaging techniques, pathogenesis, magnetic resonance imaging, diffusion tensor imaging, metabolic changes, neural regeneration