中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (3): 567-572.doi: 10.4103/1673-5374.293158

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

完全性脊髓损伤会导致运动功能核心区域的迁移

  

  • 出版日期:2021-03-15 发布日期:2020-12-17
  • 基金资助:

    中国国家自然科学基金项目(61534003,81371663);东南大学生物电子学国家重点实验室开放项目;南通市“ 226工程”项目;“六个人才高峰”项目(SWYY-116);江苏省研究生研究与实践创新计划项目(KYCX18_2424)

Influence of spinal cord injury on core regions of motor function

Xiao-Yan Shen1, 2, *, Chun-Ling Tao1, Lei Ma1, Jia-Huan Shen1, Zhi-Ling Li1, Zhi-Gong Wang2, 3, Xiao-Ying Lü4#br#   

  1. 1 School of Information Science and Technology, Nantong University, Nantong, Jiangsu Province, China;  2 Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China;  3 Institute of RF and OE-ICs, Southeast University, Nanjing, Jiangsu Province, China;  4 State Key Laboratory of Bioelectronics, Southeast University, Nanjing, Jiangsu Province, China
  • Online:2021-03-15 Published:2020-12-17
  • Contact: Xiao-Yan Shen, PhD, xiaoyansho@ntu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 61534003 (to ZGW), 81371663 (to XYS); Opening Project of State Key Laboratory of Bioelectronics in Southeast University (to XYS);  the “226 Engineering” Research Project of Nantong Government (to XYS); “Six Talent Peaks” Project, No. SWYY-116 (to XYS) and Postgraduate Research & Practice Innovation Program of Jiangsu Province, No. KYCX18_2424 (to CLT).

摘要:

功能性电刺激是在脊髓损伤后重建后肢运动功能的有效方法。但是目前还没有植入刺激电极的参考图谱。此次实验建立了重物打击法建立T9挫伤模型以及横断法建立T6/8/9脊髓损伤大鼠模型,然后在进行椎管内微刺激,记录其运动类型、部位和刺激诱发的阈值电流。结果发现在脊髓完全损伤后,大鼠脊髓中调控髋部屈曲运动的核心区域从T13迁移到T12,而脊髓中调控髋关节延伸的核心区域从L1迁移到T13,且迁移受横切后时间的影响,但不受横切阶段位置的影响。横切后时间越长,迁移距离越长。这位脊髓损伤后脊柱电极植入提供了参考位点。该研究已于2019年2月26日获得中国南通大学动物保护与利用委员会批准(批准号20190225-008)。

https://orcid.org/0000-0003-4551-186X (Xiao-Yan Shen)

关键词: 脊髓损伤, 运动, 神经功能, 修复, 恢复, 模型, 大鼠

Abstract: Functional electrical stimulation is an effective way to rebuild hindlimb motor function after spinal cord injury. However, no site map exists to serve as a reference for implanting stimulator electrodes. In this study, rat models of thoracic spinal nerve 9 contusion were established by a heavy-impact method and rat models of T6/8/9 spinal cord injury were established by a transection method. Intraspinal microstimulation was performed to record motion types, site coordinates, and threshold currents induced by stimulation. After transection (complete injury), the core region of hip flexion migrated from the T13 to T12 vertebral segment, and the core region of hip extension migrated from the L1 to T13 vertebral segment. Migration was affected by post-transection time, but not transection segment. Moreover, the longer the post-transection time, the longer the distance of migration. This study provides a reference for spinal electrode implantation after spinal cord injury. This study was approved by the Institutional Animal Care and Use Committee of Nantong University, China (approval No. 20190225-008) on February 26, 2019.

Key words: model, motor, neurological function, rat, recovery, repair, spinal cord injury