中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (26): 2415-2423.doi: 10.3969/j.issn.1673-5374.2013.26.002

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

精神分裂症大鼠海马和丘脑神经元代谢功能的分析

  

  • 收稿日期:2013-04-18 修回日期:2013-07-01 出版日期:2013-09-15 发布日期:2013-09-15

Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia

Guolin Ma1, Tianbin Song2, Min Chen3, Yuan Fu3, Yong Xu4, Ensen Ma1, Wu Wang1,Jiang Du5, Mingxiong Huang6   

  1. 1 Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

    2 Department of Radiology, Beijing Shunyi Hospital, Beijing 101300, China

    3 Department of Radiology, Beijing Hospital Affiliated to the Ministry of Public Health, Beijing 100730, China

    4 Department of Mental Health, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China

    5 Department of Radiology, University of California, San Diego, CA 92103-8226, USA

    6 Radiology Imaging Laboratory, Department of Radiology, University of California, San Diego, CA 92121, USA
  • Received:2013-04-18 Revised:2013-07-01 Online:2013-09-15 Published:2013-09-15
  • Contact: Min Chen, M.D., Chief physician, Professor, Doctoral supervisor, Department of Radiology, Beijing Hospital Affiliated to the Ministry of Public Health, Beijing 100730, China, Chenmin62@yahoo.com.
  • About author:Guolin Ma, M.D., Chief physician, Associate professor.

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摘要：

早期生长反应因子3调控的信号途径可影响精神分裂症的发生。鉴于此，实验将携带有早期生长反应因子3基因慢病毒颗粒转染至大鼠双侧海马齿状回区域，建立精神分裂症大鼠模型。采用Morris水迷宫空间实验检测转染后大鼠工作记忆缺损及认知功能受损情况。应用3.0T磁共振质子波谱成像技术检测此模型大鼠双侧海马及丘脑的神经元代谢物含量。发现转染后大鼠海马的胆碱复合物含量显著增加，而丘脑N-乙酰天门冬氨酸复合物值及N-乙酰天门冬氨酸复合物与肌酸-磷酸肌酸复合物比值有所减低。说明3.0T磁共振质子波谱成像技术能对早期生长反应因子3基因转染精神分裂症大鼠大脑进行活体神经元代谢产物检测，证明此时该模型大鼠海马及丘脑同时存在神经元代谢功能异常。

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