中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (3): 301-307.doi: 10.4103/1673-5374.128228

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

针灸使海洛因复吸大鼠中脑腹侧被盖区结构趋向正常

  

  • 收稿日期:2014-01-28 出版日期:2014-02-15 发布日期:2014-02-15

Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse

Rongjun Zhang1, Xinghui Cai1, Xiaoge Song1, Chaoyang Dong2, Xiaorong Hou1, Lei Lv1   

  1. 1 Anhui University of Chinese Medicine, Hefei, Anhui Province, China
    2 Anhui Academy of Medical Sciences, Hefei, Anhui Province, China
  • Received:2014-01-28 Online:2014-02-15 Published:2014-02-15
  • Contact: Xiaoge Song, Anhui University of Chinese Medicine, Hefei 230038, Anhui Province, China, zsongxg0128@163.com.

Abstract:

Drugs can cause obvious damage to the brain. To verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes, this study established a rat model of heroin relapse using intramuscular injection of increasing amounts of heroin. During the detoxification period, rat models received acupuncture at Baihui (DU20) and Dazhui (DU14). Electron microscopy demonstrated that the structure of the ventral tegmental area in heroin relapse rats gradually became normalized after acupuncture treatment. Immunohistochemical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. Moreover, the effects were similar to that of methadone, a type of medicine called an opioid. Results suggested that acupuncture at Baihui and Dazhui protected brain neurons against injury in rats with heroin relapse by promoting brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression.

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