中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (8): 1313-1321.doi: 10.4103/1673-5374.235217

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

中枢神经系统损伤和修复中的Eph/ephrin双向信号传导通路

  

  • 收稿日期:2018-04-09 出版日期:2018-08-15 发布日期:2018-08-15
  • 基金资助:

    中国国家自然科学基金项目（81371312，81030021），国家重点基础研究发展计划（973计划）（2011CB504403）

 Roles of Eph/ephrin bidirectional signaling during injury and recovery of the central nervous system

Yue Wan1, Jin-Shan Yang2, 3, Li-Cai Xu4, Xiao-Jiang Huang2, Wei Wang2, Min-Jie Xie2   

  1. 1 Department of Neurology, The Third People’s Hospital of Hubei Province, Wuhan, Hubei Province, China;
    2 Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China;
    3 Department of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, China;
    4 Department of Neurological Rehabilitation Center, The Third People’s Hospital of Hubei Province, Wuhan, Hubei Province, China
  • Received:2018-04-09 Online:2018-08-15 Published:2018-08-15
  • Contact: Yue Wan, M.D. or Min-Jie Xie, Ph.D., xie_minjie@126.com or wylydia@aliyun.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81371312, 81030021; the National Basic Research Development Program of China (973 Program), No. 2011CB504403.

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摘要：

神经元、胶质细胞和内皮细胞等多种细胞参与中枢神经系统损伤后复杂的病理过程，仅以中枢神经系统损伤后神经元死亡的分子机制为目标，不能达到减轻神经损伤或改善功能恢复的目的。由于Eph和ephrin分布广泛，在神经元和星形胶质细胞中都具有独特的双向信号通路，因而引起了研究者的广泛关注。Eph/ephrin在发育过程中的双向信号调节作用已在既往研究中进行报道，最近的研究表明Eph/ephrin双向信号通路在多种部位以及细胞中存在，尤在成人中枢神经系统中具有重要作用。文章重点讨论了Eph/ephrin双向信号传导通路在中枢神经系统损伤和修复的作用。Eph/ephrin复合物介导神经和血管生成，促进胶质瘢痕形成，调节内分泌水平，抑制髓鞘形成，加剧炎症以及损伤引起的神经性疼痛，并且Eph和ephrin相互作用被认为是血管生成的关键。目前Eph/ephrin在神经损伤中的作用已开始被更多研究者们关注。

orcid:0000-0002-0733-7111(Yue Wan)

关键词: 神经再生, Eph/Ephrin, 双向调控, 中枢神经系统, 损伤, 修复, 神经元, 神经胶质细胞

Abstract:

Multiple cellular components, including neuronal, glial and endothelial cells, are involved in the sophisticated pathological processes following central nervous system injury. The pathological process cannot reduce damage or improve functional recovery by merely targeting the molecular mechanisms of neuronal cell death after central nerve system injuries. Eph receptors and ephrin ligands have drawn wide attention since the discovery of their extensive distribution and unique bidirectional signaling between astrocytes and neurons. The roles of Eph/ephrin bidirectional signaling in the developmental processes have been reported in previous research. Recent observations suggest that Eph/ephrin bidirectional signaling continues to be expressed in most regions and cell types in the adult central nervous system, playing diverse roles.The Eph/ephrin complex mediates neurogenesis and angiogenesis, promotes glial scar formation, regulates endocrine levels, inhibits myelin formation and aggravates inflammation and nerve pain caused by injury.The interaction between Eph and ephrin is also considered to be the key to angiogenesis. This review focuses on the roles of Eph/ephrin bidirectional signaling in the repair of central nervous system injuries.

Key words: nerve regeneration, Eph/ephrin, bidirectional signaling, central nervous system, injury, recovery, neurons, glial cells