中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (12): 2528-2533.doi: 10.4103/1673-5374.313055

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

面肌联动患者存在相关脑区结构重塑现象

  

  • 出版日期:2021-12-15 发布日期:2021-05-17
  • 基金资助:

    国家重点科研项目（2018YFC20016000，2018YFC2001604）；上海交通大学医学与工程多学科研究基金项目（YG 2016QN13）；上海市卫生健康委员会智能医疗计划项目（2018ZHYL0216）；上海申康医院发展中心临床科技创新项目（SHDC12018126）；上海市卫生健康委员会加快中医药发展三年行动计划项目（ZY(2018-2020)-CCCX-2001-06）

Structural remodeling in related brain regions in patients with facial synkinesis

Jia-Jia Wu1, Ye-Chen Lu2, Mou-Xiong Zheng1, 3, Xu-Yun Hua1, 3, Chun-Lei Shan1, 4, Wei Ding5, *, Jian-Guang Xu1, 4, *   

  1. 1Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; 2Wound Healing Center, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; 3Department of Trauma and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; 4School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; 5Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  • Online:2021-12-15 Published:2021-05-17
  • Contact: Jian-Guang Xu, MD, PhD, xjg@shutcm.edu.cn; Wei Ding, MD, PhD, drdingwei@outlook.com.
  • Supported by:
    This study was financially supported by the National Key R&D Program of China, Nos. 2018YFC2001600 (to JGX), 2018YFC2001604 (to CLS); Shanghai Jiao Tong University Multidisciplinary Research Fund of Medicine and Engineering, China, No. YG 2016QN13 (to WD); Intelligent Medical Program of Shanghai Health Commission, China, No. 2018ZHYL0216 (to CLS); Clinical Science and Technology Innovation Project of Shanghai Shen Kang Hospital Development Center, China, No. SHDC12018126 (to JGX and CLS); and Shanghai Health Commission Accelerated the Development of Traditional Chinese Medicine Three-Year Action Plan Project, China, No. ZY(2018-2020)-CCCX-2001-06 (to CLS).

PDF

122

摘要：

面肌联动是周围性面瘫的后遗症，即使经过改良手术技术分离周围的面神经分支，也很难使患者改善。长期运动控制功能障碍是否会导致不可逆性大脑结构可塑性的变化？为揭示面肌联动的大脑结构机制变化，在上海交通大学医学院附属第九人民医院进行了此次观察性病例对照试验。选择20例面肌联动患者（2男18女，年龄33.35 ± 6.97岁）以及19名健康志愿者（2男17女，年龄33.21 ± 6.75岁），行基于体素和表面形态学的磁共振分析。（1）与健康志愿者相比，面肌联动患者的脑容量没有出现明显改变，对侧颞上回和颞下回的皮质厚度以及同侧楔前叶的沟回深度显著降低，且同侧楔前叶的沟回深度与患者的抑郁严重程度呈负相关；（2）结果提示周围性面瘫后遗面肌联动患者在相关脑区出现灰质结构的重塑改变。试验于2017年9月13日经上海交通大学医学院附属第九人民医院伦理审查委员会批准（批准号2017-365-T267），并于2018年1月25日在中国临床试验注册中心注册（注册号 ChiCTR1800014630）。

https://orcid.org/0000-0001-7515-3958 (Jia-Jia Wu); 

https://orcid.org/0000-0003-0601-3403 (Jian-Guang Xu); 

https://orcid.org/0000-0002-1505-0217 (Wei Ding)

关键词: 面肌联动, 大脑可塑性, 基于体素形态学, 基于表面形态学, 皮质厚度, 沟回深度, 面神经麻痹, 周围神经损伤

Abstract: Facial synkinesis is a troublesome sequelae of facial nerve malfunction. It is difficult to recover from synkinesis, despite improved surgical techniques for isolating the peripheral facial nerve branches. Furthermore, it remains unclear whether long-term dysfunction of motor control can lead to irreversible plasticity-induced structural brain changes. This case-control study thus investigated the structural brain alterations associated with facial synkinesis. The study was conducted at Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, China. Twenty patients with facial synkinesis (2 male and 18 female, aged 33.35 ± 6.97 years) and 19 healthy volunteers (2 male and 17 female, aged 33.21 ± 6.75 years) underwent magnetic resonance imaging, and voxel-based and surface-based morphometry techniques were used to analyze data. There was no significant difference in brain volume between patients with facial synkinesis and healthy volunteers. Patients with facial synkinesis exhibited a significantly reduced cortical thickness in the contralateral superior and inferior temporal gyri and a reduced sulcal depth of the ipsilateral precuneus compared with healthy volunteers. In addition, sulcal depth of the ipsilateral precuneus was negatively correlated with the severity of depression. These findings suggest that there is a structural remodeling of gray matter in patients with facial synkinesis after facial nerve malfunction. This study was approved by the Ethics Review Committee of the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, China (approval No. 2017-365-T267) on September 13, 2017, and was registered with the Chinese Clinical Trial Registry (registration number: ChiCTR1800014630) on January 25, 2018.

Key words: brain plasticity, cortical thickness, depression, facial nerve paralysis, facial synkinesis, peripheral nerve injury, sulcal depth, structural remodeling, surface-based morphometry, voxel-based morphometry

中图分类号: