中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (7): 1509-1516.doi: 10.4103/1673-5374.387968

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

加巴喷丁类药物治疗脑卒中:当前观点

  

  • 出版日期:2024-07-15 发布日期:2023-11-28
  • 基金资助:
    国家重点研发计划项目(2020YFC2008302);国家自然科学基金项目(81673631);四川省科技计划项目(2020YFH0059)

Gabapentinoids for the treatment of stroke

Ying Zhang1, Chenyu Zhang1, Xiaoli Yi1, Qi Wang1, Tiejun Zhang2, Yuwen Li1, *   

  1. 1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; 2Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Yuwen Li, PhD, zgsd.lyw@hotmail.com.
  • Supported by:
    This work was supported by the National Key R&D Program of China, No. 2020YFC2008302; the National Natural Science Foundation of China, No. 81673631; and the Science and Technology Program of Sichuan Province, No. 2020YFH0059 (all to YL).

摘要:

加巴喷肽类药物(普瑞巴林和加巴喷丁)已成功用于治疗神经性疼痛和预防局灶性癫痫。最近有研究表明,加巴喷肽类药物在调节神经组织中神经递质释放、氧化应激和炎症方面具有显著的作用,这与其调节电压门控钙通道的作用机制相匹配。此次综述阐述了加巴喷丁类药物的使用历史和配体结合位点,然后系统总结了加巴喷丁类药物在缺血性脑卒中、脑出血、蛛网膜下腔出血、脑卒中后癫痫发作、脑卒中后皮质扩散去极化、脑卒中后疼痛和脑卒中后神经再生临床前和临床研究进展,还讨论了加巴喷丁类药物在脑卒中中的潜在靶点。然而,现有的结果对加巴喷丁类药物治疗脑卒中及相关疾病的效果仍不确定,还需进一步临床前和临床试验来检验其在脑卒中的治疗潜力。因此提示,加巴喷丁类药物在治疗脑卒中疾病方面既有机会,也有挑战。

https://orcid.org/0000-0002-6218-148X (Yuwen Li)

关键词: 脑卒中, 加巴喷丁, 蛛网膜下腔出血, 脑出血, 脑卒中后疼痛, 皮质扩散去极化

Abstract: Gabapentinoid drugs (pregabalin and gabapentin) have been successfully used in the treatment of neuropathic pain and in focal seizure prevention. Recent research has demonstrated their potent activities in modulating neurotransmitter release in neuronal tissue, oxidative stress, and inflammation, which matches the mechanism of action via voltage-gated calcium channels. In this review, we briefly elaborate on the medicinal history and ligand-binding sites of gabapentinoids. We systematically summarize the preclinical and clinical research on gabapentinoids in stroke, including ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, seizures after stroke, cortical spreading depolarization after stroke, pain after stroke, and nerve regeneration after stroke. This review also discusses the potential targets of gabapentinoids in stroke; however, the existing results are still uncertain regarding the effect of gabapentinoids on stroke and related diseases. Further preclinical and clinical trials are needed to test the therapeutic potential of gabapentinoids in stroke. Therefore, gabapentinoids have both opportunities and challenges in the treatment of stroke. 

Key words: cortical spreading depolarization, gabapentinoid, intracerebral hemorrhage, pain after stroke, stroke, subarachnoid hemorrhage