中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (10): 2249-2258.doi: 10.4103/1673-5374.389358

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

生长激素可促进下丘脑损伤后的轴突重建

  

  • 出版日期:2024-10-15 发布日期:2024-01-29
  • 基金资助:
    广东省基础与应用基础研究基金项目(2021A1515011371,2021A1515110290,2020A1515110564,2023A1515010150);广州市科技规划项目(202102020977);国家自然科学基金项目(82201516,81900709);南方医科大学南方医院院长基金项目(2019C001,2019C016,2021C045)

Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

Kai Li#, Zhanpeng Feng#, Zhiwei Xiong#, Jun Pan, Mingfeng Zhou, Weizhao Li, Yichao Ou, Guangsen Wu, Mengjie Che, Haodong Gong, Junjie Peng, Xingqin Wang, Songtao Qi*, Junxiang Peng*   

  1. Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
  • Online:2024-10-15 Published:2024-01-29
  • Contact: Junxiang Peng, PhD, pjxlaozong@126.com; Songtao Qi, PhD, sjwkqisongtao@126.com.
  • Supported by:
    This study was supported by the Guangdong Basic and Applied Basic Research Foundation, Nos. 2021A1515011371 (to JP), 2021A1515110290 (to YO), 2020A1515110564 (to XW), and 2023A1515010150 (to MZ); Science and Technology Planning Project of Guangzhou, No. 202102020977 (to ZF); the National Natural Science Foundation of China, Nos. 82201516 (to YO) and 81900709 (to ZF); and President Foundation of Nanfang Hospital, Southern Medical University, Nos. 2019C001 (to MZ), 2019C016 (to XW), 2021C045 (to YO).

摘要:

既往研究显示,生长激素可调节下丘脑相关的能量代谢、应激和激素释放,因此生长激素在治疗下丘脑损伤方面存在巨大潜力。实验经颅顶入路通过3D打印刀结合电解损伤损伤雄性小鼠下丘脑垂体柄损伤,建立了特异性下丘脑轴突损伤模型,而后以生长激素腹腔注射进行干预治疗。结果可见,生长激素可通过促进胰岛素样生长因子1及其受体表达,促进下丘脑神经元的存活以及从下丘脑正中隆起到垂体后叶的轴突再生和血管重建,从而减轻了下丘脑损伤所致的中枢性尿崩症和情绪焦虑。这一结果提示,生长激素可通过影响生长激素-胰岛素样生长因子1轴促进下丘脑损伤后轴突的重建。

https://orcid.org/0000-0002-4380-7301 (Junxiang Peng); https://orcid.org/0000-0001-7600-9528 (Songtao Qi)

关键词:

生长激素, 再生, 下丘脑, 胰岛素样生长因子1, 催产素, 损伤, 垂体柄, 精氨酸加压素

Abstract: Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis.

Key words: arginine vasopressin, growth hormone, hypothalamo-neurohypophyseal system, hypothalamus, injury, insulin-like growth factor 1, oxytocin, regeneration