中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (9): 4290-4296.doi: 10.4103/NRR.NRR-D-25-01291

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

生物材料凝胶驱动内源性神经发生促进成人创伤性皮质损伤后的功能恢复


  

  • 出版日期:2026-09-15 发布日期:2026-05-21
  • 基金资助:
    国家自然科学基金(82272171、8271403、81941011、31971279、31730030); 清华大学精准医学基金会(10001020129)

Biomaterial gels drive endogenous neurogenesis to support functional recovery after adult traumatic cortical injury

Jinting Wu1, #, Peng Hao2, #, Hongmei Duan2, #, Wen Zhao2, Yudan Gao2, Zhiqiang Cui1, *, Zhaoyang Yang2, *, Xiaoguang Li2, *   

  1. 1Department of Neurosurgery, Tsinghua University Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China; 
    2Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
  • Online:2026-09-15 Published:2026-05-21
  • Contact: Zhaoyang Yang, PhD, wack_lily@163.com; Zhiqiang Cui, PhD, 1656957600@qq.com; Xiaoguang Li, PhD, lxgchina@sina.com.
  • Supported by:
    This study was supported by the National Natural Science Foundation of China, Nos. 82272171 (to ZY), 82271403 (to XL), 81941011 (to XL), 31971279 (to ZY), 31730030 (to XL); Tsinghua Precision Medicine Foundation, No. 10001020129 (to JW).

摘要:

成年哺乳动物大脑海马神经发生微环境(神经发生区域)内源性神经干/祖细胞的激活与神经元分化,被视为恢复认知和记忆功能的潜在基础。然而,在创伤性皮质脑损伤后——由于炎症、水肿及缺氧缺血应激等抑制性因素,局部微环境变得不利。这些条件阻碍了激活的内源性神经干/祖细胞向受损皮质迁移及其后续的神经元分化。近年来大量研究证实,生物降解生物材料可改善损伤区域微环境并促进神经再生。研究报道了一种可生物降解的生物材料——壳聚糖-明胶-胶原蛋白凝胶,通过注射至皮质损伤区域发挥作用。研究发现壳聚糖-明胶-胶原蛋白凝胶通过抑制炎症和瘢痕浸润,同时促进新生血管形成,为神经修复建立有利的微环境。由此使激活的内源性“种子”细胞——内源性神经干/祖细胞——能够迁移至皮质损伤区域并产生新神经元,最终促进功能恢复。该研究揭示了一种基于新型生物材料的治疗策略,可用于创伤性脑损伤、脑卒中及其他神经系统疾病的治疗。


https://orcid.org/0000-0001-8313-6998 (Zhaoyang Yang); 

https://orcid.org/0000-0003-4480-3676 (Xiaoguang Li); 

https://orcid.org/0009-0006-6913-9643 (Zhiqiang Cui)


关键词: 创伤性皮质脑损伤, 生物材料凝胶-壳聚糖-明胶-胶原蛋白凝胶, 内源性神经干细胞, 新生神经元, 功能恢复

Abstract:

Activation and neuronal differentiation of endogenous neural stem/progenitor cells within the hippocampal neurogenic niche (a neurogenic region) of the adult mammalian brain are considered potential bases for restoration of cognitive and memory functions. However, following traumatic cortical brain injury (i.e., injuries in a non-neurogenic region), the local microenvironment becomes hostile due to the presence of inhibitory factors such as inflammation, edema, and hypoxic–ischemic stress. These conditions hinder the migration and subsequent neuronal differentiation of activated neural stem/progenitor cells into the injured cortex. Numerous recent studies have confirmed that biomaterials can improve the microenvironment of the injured area and promote nerve regeneration. In this study, we report the findings obtained by injecting a biodegradable chitosan–gelatin–collagen gel into the cortical lesion area. We observed that the chitosan–gelatin–collagen gel established a permissive microenvironment for neural repair by suppressing inflammation and scar infiltration while promoting neovascularization. Thus, it enabled activated endogenous “seed” cells, i.e., neural stem/progenitor cells, to migrate into the cortical lesion area and generate new neurons and thereby facilitate functional recovery. These findings represent a novel biomaterial-based therapeutic strategy for the treatment of traumatic cortical brain injury, stroke, and other neurological disorders.

Key words: biomaterial gel, chitosan–gelatin–collagen gel, endogenous neural stem cell, functional recovery, newborn neuron, traumatic cortical brain injury