中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (11): 2089-2097.doi: 10.4103/1673-5374.282269

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

重复经颅磁刺激在脑卒中康复治疗中研究热点变化及有效性分析

  

  • 出版日期:2020-11-15 发布日期:2020-08-23

Research hotspots and effectiveness of repetitive transcranial magnetic stimulation in stroke rehabilitation

Ai-Hua Xu, Yong-Xin Sun   

  1. Department of Rehabilitation Medicine, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
  • Online:2020-11-15 Published:2020-08-23
  • Contact: Yong-Xin Sun,sunyongxin@cmu.edu.cn.

摘要:

重复经颅磁刺激作为一种新型康复治疗手段,是一种无痛性、非侵入性改变大脑兴奋性的治疗方法,目前已广泛应用于脑卒中患者的神经康复治疗中。作者应用CiteSpace软件,对Web of Science 数据库中收录的1999-2019年重复经颅磁刺激在脑卒中康复治疗中应用的315篇文章进行了可视化分析,以期明确该领域不同时期的研究热点和动态前沿等问题渐进性的揭示过程。目前较为公认的结论是:(1)重复经颅磁刺激对皮质下脑卒中患者运动功能恢复具有积极作用;(2)在脑卒中患者未受影响的脑半球接受低频重复经颅磁刺激可能比在受影响的脑半球接受高频重复经颅磁刺激更有利;(3)低频重复经颅磁刺激已成为慢性脑中风后非流畅性失语症患者给予神经康复和语言补救的潜在治疗工具;(4)但这些经典临床研究也存在着样本量较少及检验效能较低的缺陷,说明未来仍需要进行前瞻性、多中心、大样本、随机对照的临床试验研究,进一步验证各种重复经颅磁刺激方案对脑卒中患者康复治疗的有效贡献。

orcid: 0000-0002-1166-1627 (Yong-Xin Sun)

关键词: 经颅磁刺激, 重复经颅磁刺激, 脑卒中, 康复, 可视化分析, 运动恢复, 卒中康复

Abstract: Repetitive transcranial magnetic stimulation, as a relatively new type of rehabilitation treatment, is a pain- less and non-invasive method for altering brain excitability. Repetitive transcranial magnetic stimulation has been widely used in the neurorehabilitation of stroke patients. Here, we used CiteSpace software to visually analyze 315 studies concerning repetitive transcranial magnetic stimulation for stroke rehabili- tation from 1999 to 2019, indexed by Web of Science, to clarify the research hotspots in different periods and characterize the gradual process of discovery in this field. We found that four main points were gen- erally accepted: (1) repetitive transcranial magnetic stimulation has a positive effect on motor function recovery in patients with subcortical stroke; (2) it may be more advantageous for stroke patients to receive low-frequency repetitive transcranial magnetic stimulation in the unaffected hemispheres than to receive high-frequency repetitive transcranial magnetic stimulation in affected hemisphere; (3) low-frequency repetitive transcranial magnetic stimulation has become a potential therapeutic tool for patients with non-fluent aphasia after chronic stroke for neurological rehabilitation and language recovery; and (4) there are some limitations to these classic clinical studies, such as small sample size and low test efficiency. Our assessment indicates that prospective, multi-center, large-sample, randomized controlled clinical trials are still needed to further verify the effectiveness of various repetitive transcranial magnetic stimulation pro- grams for the rehabilitation of stroke patients.

Key words: data visualization, motor recovery, rehabilitation, repetitive transcranial magnetic stimulation, stroke, stroke rehabilitation, transcranial magnetic stimulation