中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (18): 1702-1713.

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

孕期乙醇暴露子代认知功能障碍治疗的新靶点

  

  • 收稿日期:2013-01-09 修回日期:2013-04-23 出版日期:2013-06-25 发布日期:2013-06-25

A new treatment for cognitive disorders related to in utero exposure to alcohol

Shuang Li1, 2, Yan Zhang1, 2, Feng Zhu3, Bin Zhang3, Jianying Lin3, Chunyang Xu4, 5, Wancai Yang6, Wei Hao1, 5, Ruiling Zhang1, 5   

  1. 1 Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China
    2 Department of Physiology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China
    3 First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China
    4 Department of Immunology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China
    5 Henan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang 453003, Henan Province, China
    6 School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Henan Province, China
  • Received:2013-01-09 Revised:2013-04-23 Online:2013-06-25 Published:2013-06-25
  • Contact: Ruiling Zhang, Ph.D., Professor, Chief phycisian, Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China; Henan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang 453003, Henan Province, China, zhangruilingxx@163.com.
  • About author:Shuang Li★, Master, Lecturer.

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摘要：

孕期乙醇暴露对胎儿神经系统的发育有明显的损伤。实验试图证实，参与突触可塑性和学习记忆的调节的细胞周期性蛋白激酶5与孕期乙醇暴露子代认知功能障碍有关。实验建立大鼠孕期乙醇暴露模型，取成年子鼠用于实验。Y-型迷宫测试结果发现，孕期乙醇暴露导致子鼠成年后学习记忆能力下降。实时荧光定量及反转录聚合酶链反应、免疫荧光、免疫沉淀法检测结果显示，子鼠海马组织中细胞周期性蛋白激酶5 mRNA、蛋白表达均上升。结果证实，细胞周期性蛋白激酶5可能介导了孕期乙醇暴露子代大鼠的认知功能障碍。

关键词: 神经再生, 基础实验, 神经发生, 孕期, 乙醇, 海马, 发育, 神经, 子代, 学习记忆, 细胞周期性蛋白激酶5, 大鼠, 基金资助文章, 图片文章

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