中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (7): 1480-1488.doi: 10.4103/1673-5374.387974

• 综述:退行性病与再生 • 上一篇    下一篇

多发性硬化中的肠道菌群:发病机制和治疗价值

  

  • 出版日期:2024-07-15 发布日期:2023-11-28

Gut flora in multiple sclerosis: implications for pathogenesis and treatment

Weiwei Zhang1, Ying Wang1, Mingqin Zhu1, Kangding Liu1, *, Hong-Liang Zhang2, *   

  1. 1Department of Neurology, the First Hospital of Jilin University, Jilin University, Changchun, Jilin Province, China; 2Department of Life Sciences, National Natural Science Foundation of China, Beijing, China
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Kangding Liu, MD, PhD, kangdingliu@163.com; Hong-Liang Zhang, MD, PhD, drzhl@hotmail.com or zhanghl@nsfc.gov.cn.

摘要:

多发性硬化是一种以中枢神经系统炎症、脱髓鞘和神经退行性变为特征的进行性炎性疾病。尽管目前的一线疗法可帮助控制多发性硬化的症状,并减缓其进展,但目前尚无治愈方法。肠脑轴是指肠道菌群与免疫、神经和内分泌系统之间的复杂通信,其连接了肠道和大脑的功能。肠道菌群的破坏,如生态失调,可导致全身性炎症、肠漏综合征和对感染的易感性增加。多发性硬化的发病机制涉及遗传和环境因素,肠道菌群可能在调节与多发性硬化相关的免疫反应中发挥着重要的作用。为开发更有效的多发性硬化治疗方法,需进一步了解脑肠轴在多发性硬化中的意义。此次综述概述了肠道菌群通过脑肠轴在多发性硬化中的作用。

https://orcid.org/0000-0002-7304-347X (Kangding Liu); https://orcid.org/0000-0001-9205-5559 (Hong-Liang Zhang)

关键词: 多发性硬化, 肠道菌群, 肠脑轴, 发病机制, 治疗

Abstract: Multiple sclerosis is an inflammatory disorder characterized by inflammation, demyelination, and neurodegeneration in the central nervous system. Although current first-line therapies can help manage symptoms and slow down disease progression, there is no cure for multiple sclerosis. The gut-brain axis refers to complex communications between the gut flora and the immune, nervous, and endocrine systems, which bridges the functions of the gut and the brain. Disruptions in the gut flora, termed dysbiosis, can lead to systemic inflammation, leaky gut syndrome, and increased susceptibility to infections. The pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors, and gut flora may play a pivotal role in regulating immune responses related to multiple sclerosis. To develop more effective therapies for multiple sclerosis, we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain axis. This review provides an overview of the role of the gut flora in multiple sclerosis

Key words: gut flora, gut-brain axis, multiple sclerosis, pathogenesis, treatment