中国神经再生研究(英文版) ›› 2024, Vol. 20 ›› Issue (2): 309-325.doi: 10.4103/NRR.NRR-D-23-00872

• 综述:脑损伤修复保护与再生 •    下一篇

神经科学新视野:太赫兹技术在脑研究中的应用

  


  • 出版日期:2025-02-15 发布日期:2024-06-18
  • 基金资助:
    国家重点研发计划项目(2017YFC0909200);国家自然科学基金项目(62075225);浙江省医药卫生科技项目(2023XY053);浙江省中医药科技项目(2023ZL703)

A new horizon for neuroscience: terahertz biotechnology in brain research

Zhengping Pu1, 2, Yu Wu3, 4, Zhongjie Zhu5 , Hongwei Zhao3, 4, *, Donghong Cui1, *   

  1. 1 Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2 Department of Psychiatry, Kangci Hospital of Jiaxing, Tongxiang, Zhejiang Province, China; 3 Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China; 4 Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Science, Shanghai, China; 5 National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China
  • Online:2025-02-15 Published:2024-06-18
  • Contact: Hongwei Zhao, PhD, zhaohw@sari.ac.cn; Donghong Cui, PhD, manyucc@126.com.
  • Supported by:
    This study was supported by grants from the National Key R&D Program of China, No. 2017YFC0909200 (to DC); the National Natural Science Foundation of China, No. 62075225 (to HZ); Zhejiang Provincial Medical Health Science and Technology Project, No. 2023XY053 (to ZP); and Zhejiang Provincial Traditional Chinese Medical Science and Technology Project, No. 2023ZL703 (to ZP).

摘要:

太赫兹技术越来越多地应用于各种生物医学领域,尤其在脑科学领域显示出巨大的应用潜力。文章综述了太赫兹技术的发展及其在神经精神病学领域的应用。现有证据表明,太赫兹波谱和太赫兹成像技术在淀粉样蛋白疾病、脑血管疾病、神经胶质瘤、精神疾病、创伤性脑损伤和髓鞘缺陷的诊断中具有广泛的应用前景。体外和动物实验也证实太赫兹技术在一些神经精神疾病中具有潜在的治疗价值。尽管太赫兹电磁波与生物系统之间相互作用的确切机制尚不完全清楚,但该领域的研究进展显示出其在非侵入性诊断和治疗应用的巨大潜力。但是THz辐射的生物效应具有双面性,因此其生物安全性需要更多的探索。作者认为,太赫兹技术具有的独特优势,有可能使其成为神经精神病学领域的一种有前途的方法。

https://orcid.org/0000-0001-8967-3591 (Hongwei Zhao); https://orcid.org/0000-0002-9140-1445 (Donghong Cui)

关键词: 太赫兹技术, 太赫兹光谱, 太赫兹成像, 神经科学, 脑, 神经精神病学, 神经元, 太赫兹辐射, 生物效应, 非热效应

Abstract: Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences. In this article, we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry. Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease, cerebrovascular disease, glioma, psychiatric disease, traumatic brain injury, and myelin deficit. In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases. Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood, the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications. However, the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications. This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

Key words: biological effect, brain, neuron, neuropsychiatry, neuroscience, non-thermal effect, terahertz imaging, terahertz radiation, terahertz spectroscopy, terahertz technology